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Titolo:
Sequential use of gadolinium chelate and mangafodipir trisodium for the assessment of focal liver lesions: Initial observations
Autore:
Martin, DR; Semelka, RC; Chung, JJ; Balci, NC; Wilber, K;
Indirizzi:
Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 adiol, Chapel Hill, NC 27599 USA
Titolo Testata:
MAGNETIC RESONANCE IMAGING
fascicolo: 8, volume: 18, anno: 2000,
pagine: 955 - 963
SICI:
0730-725X(200010)18:8<955:SUOGCA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANGANESE DIPYRIDOXAL-DIPHOSPHATE; MRI CONTRAST AGENT; GD-EOB-DTPA; MN-DPDP; HEPATOCELLULAR-CARCINOMA; BILIARY OBSTRUCTION; MNDPDP; ENHANCEMENT; TUMORS; RATS;
Keywords:
liver; contrast agents; gadolinium; manganese; mangafodipir trisodium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Semelka, RC Univ N Carolina, Dept Radiol, CB 7510, Chapel Hill, NC 27599 USA Univ N Carolina CB 7510 Chapel Hill NC USA 27599 NC 27599 USA
Citazione:
D.R. Martin et al., "Sequential use of gadolinium chelate and mangafodipir trisodium for the assessment of focal liver lesions: Initial observations", MAGN RES IM, 18(8), 2000, pp. 955-963

Abstract

The purpose of this study was to assess the feasibility of sequential administration of 2 different MR imaging contrast agents using a single visit protocol to image focal liver abnormalities. Twenty-one patients with known or suspected liver lesions were included in the study. All patients received a bolus intravenous injection of gadolinium chelate (Gd) and dynamically enhanced imaging performed. The patients then received an injection of mangafodipir trisodium (Mn) contrast and a second scan performed with an average delay of 62 min after the Gd bolus injection. The images were evaluated to determine the appearance of liver lesions after administration of each contrast agent, and For evidence of prior Gd administration adversely affecting evaluation of images acquired after Mn administration. Focal liver lesions were present in 19 patients, including 8 with liver metastases, 1 with liver lymphoma, 6 with hemangiomas, 3 with focal nodular hyperplasia (FNH), and 1 with hepatic abscess. In 2 other patients no liver lesions were identified in either the post-Gd or post-Gd-post-Mn scans. All malignant lesionsidentified on the post-Gd scan were also identified on post-Gd-post-Mfi scans. Although the potential benefit for increasing detection sensitivity for hepatic metastases was nor demonstrated, this is a preliminary series. This study does demonstrate the practicality for use a single visit sequential Gd-Mn protocol described here, with possible application of this technique for further assessment of the utility of combining Gd and Mn for detection of liver metastases. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:40:02