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Titolo:
Correlation of hemodynamic impact and morphologic degree of renal artery stenosis in a canine model
Autore:
Schoenberg, SO; Bock, M; Kallinowski, F; Just, A;
Indirizzi:
German Canc Res Ctr, Dept Radiol, Heidelberg, Germany German Canc Res CtrHeidelberg Germany Dept Radiol, Heidelberg, Germany Univ Heidelberg Hosp, Dept Surg, Heidelberg, Germany Univ Heidelberg HospHeidelberg Germany Dept Surg, Heidelberg, Germany Univ Heidelberg, Inst Physiol & Pathophysiol, Heidelberg, Germany Univ Heidelberg Heidelberg Germany & Pathophysiol, Heidelberg, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 12, volume: 11, anno: 2000,
pagine: 2190 - 2198
SICI:
1046-6673(200012)11:12<2190:COHIAM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; BLOOD-FLOW; CARDIAC-CATHETERIZATION; VASCULAR-DISEASE; AUTO-REGULATION; RENIN RELEASE; CONSCIOUS DOG; AUTOREGULATION; PROGRESSION; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Just, A Univ N Carolina, Dept Cell & Mol Physiol, Med Sci Res Bldg,CB 7545, ChapelHill, NC 27599 USA Univ N Carolina Med Sci Res Bldg,CB 7545 Chapel Hill NC USA 27599
Citazione:
S.O. Schoenberg et al., "Correlation of hemodynamic impact and morphologic degree of renal artery stenosis in a canine model", J AM S NEPH, 11(12), 2000, pp. 2190-2198

Abstract

In a noninvasive comprehensive magnetic resonance (MR) examination, the morphologic degree of renal artery stenosis was correlated to corresponding changes in renal artery flow dynamics. Different degrees of stenosis were created with the use of a chronically implanted inflatable arterial cuff in seven dogs. For each degree of stenosis, an ultrafast three-dimensional gadolinium MR angiography with high spatial resolution was performed, followed by cardiac-gated MR flow measurements with high temporal resolution for determination of pulsatile flow profiles and mean flow. Flow was also measuredby a chronically implanted flow probe. In three of the dogs, trans-stenotic pressure gradients (DeltaP) also were measured via implanted catheters. Five different degrees of stenosis could be differentiated in the MR angiograms (0%, 30%, 50%, 80%, >90%). The MR flow data agreed with the flow probe within +/-20%. Stenoses between 30 and 80% gradually reduced the early systolic peak (Max(1)) of the flow profile but only minimally affected the midsystolic peak (Max(2)) or mean flow. Stenoses of more than 90% significantlydepressed mean flow by more than 50%. The ratio between Max(1) and Max(2) (Rmax(1/2)) gradually fell with the degree of stenosis. The onset of significant mean flow reduction and DeltaP was indicated by a drop of Rmax(1/2) below 1 to 1.2. Thus, the analysis of high-resolution flow profiles allows detection of early hemodynamic changes even at degrees of stenoses not associated with a reduction of mean flow. Rmax(1/2) allows differentiation of the grade of hemodynamic compronrise for a given morphologic stenosis independent of mean flow in a single comprehensive MR examination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:00:47