Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women
Autore:
Rosano, GMC; Webb, CM; Chierchia, S; Morgani, GL; Gabraele, M; Sarrel, PM; de Ziegler, D; Collins, P;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Sch Med, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med London England SW3 6LY gland Osped San Raffaele, Dept Cardiol, Rome, Italy Osped San Raffaele Rome Italy d San Raffaele, Dept Cardiol, Rome, Italy Royal Brompton & Harefield NHS Trust, London, England Royal Brompton & Harefield NHS Trust London England st, London, England Yale Univ, Sch Med, Dept Obstet & Gynecol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 bstet & Gynecol, New Haven, CT 06510 USA Columbia Labs, Paris, France Columbia Labs Paris FranceColumbia Labs, Paris, France
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 7, volume: 36, anno: 2000,
pagine: 2154 - 2159
SICI:
0735-1097(200012)36:7<2154:NPBNMA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HORMONE REPLACEMENT THERAPY; HEART-DISEASE; MONKEYS; RISK; INHIBITION; INFARCTION; ESTRADIOL; RESPONSES; ANGINA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Collins, P Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Sch Med, Dovehouse St, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med Dovehouse St London England SW3 6LY
Citazione:
G.M.C. Rosano et al., "Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women", J AM COL C, 36(7), 2000, pp. 2154-2159

Abstract

OBJECTIVES We sought to compare the effects of estrogen/transvaginal progesterone gel with estrogen/medroxyprogesterone acetate (MPA) on exercise-induced myocardial ischemia in postmenopausal women with coronary artery disease or previous myocardial infarction, or both. BACKGROUND Estrogen therapy beneficially affects exercise-induced myocardial ischemia in postmenopausal women; however, women with an intact uterus also take progestin to protect against uterine malignancies. The effects of combination estrogen/progestin therapy on myocardial ischemia are unknown. METHODS Eighteen postmenopausal women (mean +/- SD age 59 +/- 7 years) were given 17-beta-estradiol in single-blinded manner for four weeks (1 mg/dayfor three weeks then 2 mg/day for one week). Estradiol (2 mg/day) was thencontinued, and the patients were randomized (double-blind) for 12 days to either transvaginal progesterone gel (90 mg on alternate days) and oral MPAplacebo (10 mg/day), or vice versa. After another two weeks on estradiol alone, the patients crossed over to progestin treatment and repeated the protocol on the opposite treatment. Patients underwent treadmill exercise testing after each estradiol phase and at day 10 of each progestin phase. RESULTS Exercise time to myocardial ischemia increased after the first estrogen phase as compared with baseline (mean difference with 95% confidence interval [CI]: 72 s [34 to 110], p = 0.001), and was increased by combination estradiol/progesterone therapy as compared with estradiol/MPA therapy (92 s [35 to 149], p = 0.001)). Two patients (11%) were withdrawn while taking estradiol/MPA owing to unstable angina. CONCLUSIONS Combination estrogen/transvaginal progesterone gel increases exercise time to myocardial ischemia, as compared with estrogen/MPA. These results imply that the choice of progestin in women at higher cardiovascularrisk requires careful consideration. (C) 2000 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:36:39