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Titolo:
Apolipoprotein E epsilon 4 and tardive dyskinesia in a Japanese population
Autore:
Kimura, T; Shono, M; Yokota, S; Ishizuka, K; Watanabe, M; Takamatsu, J; Miyakawa, T;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Neuropsychiat, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 ropsychiat, Kumamoto 8608556, Japan Natl Hansen Inst Kikuchi Keifuen, Kumamoto, Japan Natl Hansen Inst KikuchiKeifuen Kumamoto Japan eifuen, Kumamoto, Japan Koyodai Hosp, Kumamoto, Japan Koyodai Hosp Kumamoto JapanKoyodai Hosp, Kumamoto, Japan Kikuchi Natl Hosp, Div Clin Res, Kumamoto, Japan Kikuchi Natl Hosp Kumamoto Japan tl Hosp, Div Clin Res, Kumamoto, Japan
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 4-5, volume: 34, anno: 2000,
pagine: 329 - 332
SICI:
0022-3956(200007/10)34:4-5<329:AEE4AT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MOVEMENT-DISORDERS; ALZHEIMERS-DISEASE; VITAMIN-E; ALLELE; SCHIZOPHRENIA; RISK; GENOTYPE; AGE;
Keywords:
tardive dyskinesia; apolipoprotein E; free radicals; gender difference; Japanese;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kimura, T Kumamoto Univ, Sch Med, Dept Neuropsychiat, Honjo 1-1-1, Kumamoto 8608556,Japan Kumamoto Univ Honjo 1-1-1 Kumamoto Japan 8608556 8608556,Japan
Citazione:
T. Kimura et al., "Apolipoprotein E epsilon 4 and tardive dyskinesia in a Japanese population", J PSYCH RES, 34(4-5), 2000, pp. 329-332

Abstract

The findings that free radicals play a causative role in the occurrence oftardive dyskinesia (TD) and that apolipoprotein E (ApoE) 4 has decreased anti-oxidant activity suggest a potential link between TD and ApoE alleles. We, therefore, examined ApoE allelic frequencies in schizophrenic subjects with TD and non-TD. Serum samples were obtained from 333 DSM IV-diagnosed schizophrenic patients and 191 controls in Japan. The presence of TD was evaluated by research diagnostic criteria for TD. ApoE phenotypes of the serumsamples were determined by polyacrylamide gel isoelectricfocusing. A totalof 62 TD subjects (31 males, 31 females) were identified among all patients examined. No significant differences in ApoE allelic frequency were foundbetween TD and non-TD groups. ApoE epsilon4 allele frequency, however, wassignificantly lower in the female TD group than in the male TD group. These findings do not clearly demonstrate a certain association between TD and the epsilon4 allele, but may preliminarily reveal a difference in influenceof this allele on the development of TD between males and females. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Documento generato il 15/07/20 alle ore 21:39:07