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Titolo:
Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: Implications for Tat-mediated pathogenesis
Autore:
Benelli, R; Barbero, A; Ferrini, S; Scapini, P; Cassatella, M; Bussolino, F; Tacchetti, C; Noonan, DM; Albini, A;
Indirizzi:
Ist Nazl Ric Canc, Mol Biol Lab, Ctr Biotecnol Avanzate, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 nol Avanzate, I-16132 Genoa, Italy Ist Nazl Ric Canc, Tumor Progress Sect, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 rogress Sect, I-16132 Genoa, Italy Ist Nazl Ric Canc, Immunopharmacol Sect, I-16132 Genoa, Italy Ist Nazl RicCanc Genoa Italy I-16132 armacol Sect, I-16132 Genoa, Italy Univ Genoa, Dept Expt Med, Anat Sect, Genoa, Italy Univ Genoa Genoa Italy iv Genoa, Dept Expt Med, Anat Sect, Genoa, Italy Univ Verona, Dept Pathol, Gen Pathol Sect, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 Gen Pathol Sect, I-37100 Verona, Italy Univ Turin, Inst Canc Res & Treatment, Candiolo, Italy Univ Turin Candiolo Italy n, Inst Canc Res & Treatment, Candiolo, Italy Univ Turin, Dept Genet Biol & Biochem, Candiolo, Italy Univ Turin Candiolo Italy n, Dept Genet Biol & Biochem, Candiolo, Italy
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 6, volume: 182, anno: 2000,
pagine: 1643 - 1651
SICI:
0022-1899(200012)182:6<1643:HIVTP(>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; HIV-I TAT; KAPOSIS-SARCOMA; TRANSGENIC MICE; MONOCYTE CHEMOTAXIS; CYTOKINE EXPRESSION; FLK-1/KDR RECEPTOR; RESPIRATORY BURST; HUMAN NEUTROPHILS; GENE-EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Albini, A Ist Nazl Ric Canc, Mol Biol Lab, Ctr Biotecnol Avanzate, Largo Rosanna Benzi 10, I-16132 Genoa, Italy Ist Nazl Ric Canc Largo Rosanna Benzi10 Genoa Italy I-16132 ly
Citazione:
R. Benelli et al., "Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: Implications for Tat-mediated pathogenesis", J INFEC DIS, 182(6), 2000, pp. 1643-1651

Abstract

The extracellular activities of the human immunodeficiency virus (HIV) transactivator protein (Tat) include induction of angiogenesis and stimulationof monocyte migration, Here it is shown that polymorphonuclear leukocytes (PMNL), mostly neutrophils, rapidly invade in response to Tat in vivo and initiate the formation of new vessels, In vitro, Tat was chemotactic for PMNL and induced calcium (Ca2+) mobilization, Tat proteins with inactivating substitutions in the arginine-glycine-aspartic acid or basic domain were still active in inducing PMNL migration, whereas Tat peptides mapped the migration and Ca2+ mobilization activity to a cysteine-rich core domain, previously described as a Tat "chemokine-like" region (peptide CysL(24-51)). Tat and the CysL(24-51) peptide also induced PMNL superoxide production and the release of the angiogenic factors interleukin-X and vascular endothelial growth factor from PMNL, CysL(24-51) did not induce endothelial cell migration but was angiogenic in vivo. These data indicate that the Tat activity on PMNL is mediated by its chemokine-like region and that PMNL recruitment by Tar is linked to angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 00:56:42