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Titolo:
Susceptibility to Leishmania major infection in the absence of IL-4
Autore:
Noben-Trauth, N;
Indirizzi:
NIAID, Immunol Lab, NIH, Rockville, MD 20852 USA NIAID Rockville MD USA 20852 D, Immunol Lab, NIH, Rockville, MD 20852 USA
Titolo Testata:
IMMUNOLOGY LETTERS
fascicolo: 1, volume: 75, anno: 2000,
pagine: 41 - 44
SICI:
0165-2478(200012)75:1<41:STLMII>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-GAMMA-CHAIN; CD4+ T-CELLS; INTERFERON-GAMMA; INTERLEUKIN-4 RECEPTOR; MURINE LEISHMANIASIS; FUNCTIONAL COMPONENT; DEFICIENT MICE; LYMPHOKINE; RESISTANCE; CLONING;
Keywords:
Leishmania; IL-4; knockout; Th1/Th2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Noben-Trauth, N NIAID, Immunol Lab, NIH, 12441 Parklawn Dr, Rockville, MD 20852 USA NIAID 12441 Parklawn Dr Rockville MD USA 20852 D 20852 USA
Citazione:
N. Noben-Trauth, "Susceptibility to Leishmania major infection in the absence of IL-4", IMMUNOL LET, 75(1), 2000, pp. 41-44

Abstract

Infection with the intracellular parasite Leishmania major is the prototypical model system used to study Th1 and Th2 cytokine responses in vivo. Mouse strains that are resistant to L. major produce high levels of IFN gamma,and Th1 cytokines while susceptible BALB/c mice have elevated levels of IL-4, and Th2-associated cytokines during infection. While antibody neutralization of IL-4 or IFN gamma in vivo alters the disease patterns, infection of mice genetically deficient for IL-4 or IL-4 receptor (IL-4R alpha) yield surprising outcomes. Contrary to the Th1/Th2 paradigm, IL-4 -/- and IL-4R alpha -/- mice remain highly susceptible to L. major parasite substrain LV39. In distinct contrast, another L. major substrain, IR173, the IL-4R alpha -/- mice are highly resistant. These findings indicate a disparity between antibody treatment versus gene deletion, and more generally, challenge the role of IL-4 in promoting susceptibility to L. major. Furthermore, IL-4R alpha -/- mice reveal that the ability of L. major to escape immune clearancedepends on the parasite substrain. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:37:09