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Titolo:
Cardiac aldosterone production in genetically hypertensive rats
Autore:
Takeda, Y; Yoneda, T; Demura, M; Miyamori, I; Mabuchi, H;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 2, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Sch Med, Dept Hlth Sci, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Fukui Med Sch, Dept Internal Med 3, Fukui 91011, Japan Fukui Med Sch Fukui Japan 91011 Dept Internal Med 3, Fukui 91011, Japan
Titolo Testata:
HYPERTENSION
fascicolo: 4, volume: 36, anno: 2000,
pagine: 495 - 500
SICI:
0194-911X(200010)36:4<495:CAPIGH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; POLYMERASE CHAIN-REACTION; GENE-EXPRESSION; MESSENGER-RNA; VASCULAR ALDOSTERONE; MYOCARDIAL FIBROSIS; INDUCED HYPERTROPHY; III COLLAGEN; HEART; DEHYDROGENASE;
Keywords:
heart; rats, inbred strains; aldosterone; hypertrophy; cytochrome p450; mRNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, Y Kanazawa Univ, Sch Med, Dept Internal Med 2, 13-1 Takara Machi, Kanazawa, Ishikawa 920, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 920 apan
Citazione:
Y. Takeda et al., "Cardiac aldosterone production in genetically hypertensive rats", HYPERTENSIO, 36(4), 2000, pp. 495-500

Abstract

Aldosterone is synthesized in extra-adrenal tissues, both blood vessels and brain. We undertook the present study to determine whether the rat heart produces aldosterone and to investigate the effects of adrenalectomy, ACE inhibition, and angiotensin II on aldosterone synthesis in the heart. To clarify the pathophysiological role of cardiac aldosterone in the hypertensiveheart, we compared the synthesis of aldosterone in the hearts of stroke-prone spontaneously hypertensive rats (SHRSP) with that in Wistar-Kyoto rats. The effects of the aldosterone antagonist spironolactone on myocardial hypertrophy in adrenalectomized SHRSP were also studied. Isolated rat hearts were perfused for 2 hours, and the perfusate was analyzed with HPLC and massspectrometry. The activity of aldosterone synthase was estimated on the basis of the conversion of [C-14]deoxycorticosterone to [C-14]aldosterone. The levels of aldosterone synthase gene (CYP11B2) mRNA were determined with competitive polymerase chain reaction. Aldosterone production, the activity of aldosterone synthase, and the expression of CYP11B2 mRNA were increased in hearts from adrenalectomized rats and rats treated with angiotensin II. ACE inhibitors decreased cardiac aldosterone synthesis. Cardiac aldosterone, aldosterone synthase activity, and CYP11B2 mRNA levels in hearts from 2- and 4-week-old SHRSP were significantly greater than those of age-matched Wistar-Kyoto rats. Spironolactone prevented cardiac hypertrophy in adrenalectomized SHRSP, These results suggest that the rat heart produces aldosterone and that endogenous cardiac aldosterone may affect cardiac function and hypertrophy in hypertension in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:36:55