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Titolo:
Neuregulins and ErbB receptor expression in adult human oligodendrocytes
Autore:
Deadwyler, GD; Pouly, S; Antel, JP; Devries, GH;
Indirizzi:
Edward Hines Vet Adm Hosp, Res Serv 151, Hines, IL 60141 USA Edward Hines Vet Adm Hosp Hines IL USA 60141 erv 151, Hines, IL 60141 USA Serono Pharmaceut Res Inst, Geneva, Switzerland Serono Pharmaceut Res Inst Geneva Switzerland Inst, Geneva, Switzerland McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada McGill Univ Montreal PQ Canada ontreal Neurol Inst, Montreal, PQ, Canada Loyola Univ, Med Ctr, Dept Cell Biol Neurobiol & Anat, Maywood, IL USA Loyola Univ Maywood IL USA t Cell Biol Neurobiol & Anat, Maywood, IL USA
Titolo Testata:
GLIA
fascicolo: 3, volume: 32, anno: 2000,
pagine: 304 - 312
SICI:
0894-1491(200012)32:3<304:NAEREI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEU-DIFFERENTIATION FACTOR; GROWTH-FACTOR; SCHWANN-CELLS; SECRETE NEUREGULINS; MULTIPLE-SCLEROSIS; FACTOR HEREGULIN; TYROSINE KINASE; NERVOUS-SYSTEM; GLIAL-CELLS; ISOFORMS;
Keywords:
human; oligodendrocytes; HRG alpha; HRG beta; erbB receptors; tyrosine phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Devries, GH Edward Hines Vet Adm Hosp, Res Serv 151, Hines, IL 60141 USA Edward Hines Vet Adm Hosp Hines IL USA 60141 es, IL 60141 USA
Citazione:
G.D. Deadwyler et al., "Neuregulins and ErbB receptor expression in adult human oligodendrocytes", GLIA, 32(3), 2000, pp. 304-312

Abstract

We have previously reported that neonatal rat oligodendrocytes (OLGs) express and secrete neuregulins (NRGs) (Raabe et al., 1997). This laboratory has also shown that NRGs stimulate the differentiation of neonatal rat OLGs and that these cells express the erbB receptors far NRGs (Raabe et al., 1997). In this study, we have characterized NRG expression in adult human OLG cultures isolated from the temporal lobe resection of intractable epilepsy patients. Using immunocytochemistry and Western blotting, we find that adulthuman OLGs contain both the alpha and beta isoforms of NRGs. In addition, Western blots show that the adult human OLGs secrete both isoforms as N-glycosylated molecules. These cells also express all four erbB receptor subtypes, and possibly an activated erbB receptor. The observation that these cells synthesize and secrete their own NRGs, and possibly express a tyrosine-phosphorylated erbB receptor, is consistent with autocrine and/or paracrine signaling. Amplification of this signaling may provide a useful mechanism to stimulate differentiation of adult human OLGs in demyelinating disease. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:52:35