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Titolo:
Establishment and characterization of chromosomal aberrations in human cholangiocarcinoma cell lines by cross-species color banding
Autore:
Kim, DG; Park, SY; You, KR; Lee, GB; Kim, H; Moon, WS; Chun, YH; Park, SH;
Indirizzi:
Korea Univ, Coll Med, Dept Anat, Inst Human Genet,Sungbuk Ku, Seoul 136705, South Korea Korea Univ Seoul South Korea 136705 ungbuk Ku, Seoul 136705, South Korea Chonbuk Natl Univ, Sch Med, Res Inst Clin Med, Dept Internal Med, Chonju, South Korea Chonbuk Natl Univ Chonju South Korea Internal Med, Chonju, South Korea Chonbuk Natl Univ, Sch Med, Res Inst Clin Med, Dept Pathol, Chonju, South Korea Chonbuk Natl Univ Chonju South Korea , Dept Pathol, Chonju, South Korea
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 1, volume: 30, anno: 2001,
pagine: 48 - 56
SICI:
1045-2257(200101)30:1<48:EACOCA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; HUMAN KARYOTYPE ANALYSIS; IN-SITU HYBRIDIZATION; DRUG-RESISTANCE GENE; HEPATOCELLULAR-CARCINOMA; CARCINOEMBRYONIC ANTIGEN; ALPHA-FETOPROTEIN; PROSTATE-CANCER; PAINTING PROBES; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Park, SH Korea Univ, Coll Med, Dept Anat, Inst Human Genet,Sungbuk Ku, 126-1 Anam Dong 5 Ka, Seoul 136705, South Korea Korea Univ 126-1 Anam Dong 5 Ka Seoul South Korea 136705 h Korea
Citazione:
D.G. Kim et al., "Establishment and characterization of chromosomal aberrations in human cholangiocarcinoma cell lines by cross-species color banding", GENE CHROM, 30(1), 2001, pp. 48-56

Abstract

Cholangiocarcinoma (CC), a malignant neoplasm of the biliary epithelium, is usually fatal because of difficulty in early diagnosis and lack of availability of effective therapy. Furthermore, little is known about the genetics and biology of CC. Only a few reports concerning cytogenetic studies of CC have been published, and few cell lines have been established. We recently established four CC cell lines, designated as SCK, JCK, Cho-CK, and Choi-CK, and report the first application of cross-species color banding (RxFISH) and multiple chromosome painting for the characterization of the chromosomal rearrangements of these CC cell lines. Each cell line had unique modal karyotypic characteristics and showed a variable number of numerical and structural clonal cytogenetic aberrations. Chromosomes 3, 6, 7, 8, 12, 14, 17, and 18 were commonly involved in structural abnormalities. Homogeneously staining regions were determined in SCK and JCK, and double minute chromosomes were found in Cho-CK. The chromosomal aberrations of the four CC cell lines were effectively analyzed by RxFISH and FISH with multiple chromosome painting probes. The nonrandom rearrangements suggest candidate regions forisolation of genes related to CC. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:44:19