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Titolo:
Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na++K+)- and Ca++-ATPase activities in high glucose-treated human erythrocytes
Autore:
Jain, SK; Lim, G;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 at, Shreveport, LA 71130 USA
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 11, volume: 29, anno: 2000,
pagine: 1122 - 1128
SICI:
0891-5849(200012)29:11<1122:LADLPA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-E SUPPLEMENTATION; DIABETIC PERIPHERAL NEUROPATHY; SODIUM-POTASSIUM-ATPASE; LOW-DENSITY-LIPOPROTEIN; RED-BLOOD-CELLS; THIOCTIC ACID; DIHYDROLIPOIC ACID; SKELETAL-MUSCLE; LIPOAMIDE DEHYDROGENASE; ANTIOXIDANT TREATMENT;
Keywords:
hyperglycemia; lipid peroxidation; lipoic acid; (Na+ + K+) and Ca++-ATPases; free radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Jain, SK Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, 1501 Kings Highway, Shreveport, LA 71130 USA Louisiana State Univ 1501 Kings Highway Shreveport LA USA 71130 A
Citazione:
S.K. Jain e G. Lim, "Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na++K+)- and Ca++-ATPase activities in high glucose-treated human erythrocytes", FREE RAD B, 29(11), 2000, pp. 1122-1128

Abstract

Lipoic acid supplementation has been found to be beneficial in preventing neurovascular abnormalities in diabetic neuropathy. Insufficient (Na+ + K+)-ATPase activity has been suggested as a contributing factor in the development of diabetic neuropathy. This study was undertaken to test the hypothesis that lipoic acid reduces lipid peroxidation and glycosylation and can increase the (Na+ + K+)- and Ca++-ATPase activities in high glucose-exposed red blood cells (RBC). Washed normal human RBC were treated with normal (6 mM) and high glucose concentrations (45 mM) with 0-0.2 mM lipoic acid (mixture of S and R sterioisomers) in a shaking water bath at 37 degreesC for 24 h. There was a significant stimulation of glucose consumption by RBC in thepresence of lipoic acid both in normal and high glucose-treated RBC. Lipoic acid significantly lowered the level of glycated hemoglobin (GHb) and lipid peroxidation in RBC exposed to high glucose concentrations. High glucosetreatment significantly lowered the activities of (Na+ + K+)- and Ca++-ATPases of RBC membranes. Lipoic acid addition significantly blocked the reduction in activities of (Na+ + K+)- and Ca++ -ATPases in high glucose- treated RBC. There were no differences in lipid peroxidation, GHb and(Na+ + K+)- and Ca++-ATPase activity levels in normal glucose-treated RBC with and without lipoic acid. Thus, Lipoic acid can lower lipid peroxidation and proteinglycosylation, and increase (Na+ + K+)- and Ca++-ATPase activities in high-glucose exposed RBC, which provides a potential mechanism by which lipoic acid may delay or inhibit the development of neuropathy in diabetes. (C) 2000 Elsevier Science Inc.

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Documento generato il 25/09/20 alle ore 00:25:35