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Titolo:
Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families
Autore:
Palmer, LJ; Burton, PR; James, AL; Musk, AW; Cookson, WOCM;
Indirizzi:
Harvard Univ, Sch Med, Channing Lab, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Channing Lab, Boston, MA 02115 USA TVW Telethon Inst Child Hlth Res, Div Populat Sci, Genet Epidemiol Unit, Perth, WA, Australia TVW Telethon Inst Child Hlth Res Perth WA Australia Perth, WA, Australia Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA Brigham & Womens Hosp Boston MA USA pt Med, Channing Lab, Boston, MA USA Univ Leicester, Dept Epidemiol & Publ Hlth, Leicester, Leics, England UnivLeicester Leicester Leics England l Hlth, Leicester, Leics, England Sir Charles Gairdner Hosp, Dept Pulm Physiol, Perth, WA, Australia Sir Charles Gairdner Hosp Perth WA Australia ysiol, Perth, WA, Australia Sir Charles Gairdner Hosp, Univ Dept Med, Perth, WA, Australia Sir CharlesGairdner Hosp Perth WA Australia t Med, Perth, WA, Australia Sir Charles Gairdner Hosp, Dept Resp Med, Perth, WA, Australia Sir CharlesGairdner Hosp Perth WA Australia p Med, Perth, WA, Australia John Radcliffe Hosp, Nuffield Dept Clin Med, Wellcome Trust Ctr Human Genet, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU enet, Oxford OX3 9DU, England
Titolo Testata:
EUROPEAN JOURNAL OF HUMAN GENETICS
fascicolo: 11, volume: 8, anno: 2000,
pagine: 853 - 860
SICI:
1018-4813(200011)8:11<853:FAAHOA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOME-WIDE SEARCH; SKIN-TEST REACTIVITY; SERUM IGE LEVELS; PULMONARY-FUNCTION; BRONCHIAL RESPONSIVENESS; SUSCEPTIBILITY LOCI; GENERAL-POPULATION; IMMUNOGLOBULIN-E; PREVALENCE; SMOKING;
Keywords:
asthma; IgE; lung function; airway responsiveness; blood eosinophil count; genetics; variance components; Busselton Population Health Study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Palmer, LJ Harvard Univ, Sch Med, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA Harvard Univ 181 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
L.J. Palmer et al., "Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families", EUR J HUM G, 8(11), 2000, pp. 853-860

Abstract

Asthma is a common, genetically complex human disease. Elevated serum immunoglobulin E (IgE) levels, elevated blood eosinophil counts, variably reduced spirometric measures and increased airway responsiveness (AR) are physiological traits which are characteristic of asthma. We investigated the genetic and environmental components of variance of serum total and specific IgE levels, blood eosinophil counts, the forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), and AR in an Australian population-based sample of 232 Caucasian nuclear families. With the exception of FVC levels, all traits were closely associated with clinical asthma in this population. Log(e) total serum IgE levels had a narrow-sense heritability (h(N)(2)) of 47.3% (SE = 10.0%). Specific serum IgE levels against house dustmite and Timothy grass, measured as a RAST Index, had a h(N)(2), of 33.8% (SE = 7.3"/0). FEV1 levels had a h(N)(2) of 6.1% (SE = 11.6%), whilst FVC levels had a h(N)(2), of 30.6% (SE = 26.8%). AR, quantified by the log(e) dose-response slope to methacholine (DRS), had a h(N)(2) of 30.3% (SE = 12.3%). These data are consistent with the existence of important genetic determinants of the pathophysiological traits associated with asthma. Our study suggests that total and specific serum IgE levels, blood eosinophil counts and airways responsiveness to inhaled agonist are appropriate phenotypes formolecular investigations of the genetic susceptibility to asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 09:27:47