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Titolo:
The effect of transcranial magnetic stimulation on reaction time in progressive supranuclear palsy
Autore:
Molinuevo, JL; Valls-Sole, J; Valldeoriola, F;
Indirizzi:
Univ Barcelona, Fac Med, Hosp Clin, Neurol Serv,Unitat Electromiograf, Barcelona, Spain Univ Barcelona Barcelona Spain ,Unitat Electromiograf, Barcelona, Spain Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain Inst Invest BiomedAugust Pi & Sunyer Barcelona Spain Barcelona, Spain
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 11, volume: 111, anno: 2000,
pagine: 2008 - 2013
SICI:
1388-2457(200011)111:11<2008:TEOTMS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE CIRCUIT; PARKINSONS-DISEASE; SOMATOSENSORY STIMULI; RETICULAR-FORMATION; NEURONS; DIAGNOSIS; REFLEX;
Keywords:
reaction time; transcranial magnetic stimulation; startling acoustic stimulus; progressive supranuclear palsy; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Valls-Sole, J Univ Barcelona, Fac Med, Hosp Clin, Neurol Serv,Unitat Electromiograf, Villarroel 170, Barcelona, Spain Univ Barcelona Villarroel 170 Barcelona Spain elona, Spain
Citazione:
J.L. Molinuevo et al., "The effect of transcranial magnetic stimulation on reaction time in progressive supranuclear palsy", CLIN NEU, 111(11), 2000, pp. 2008-2013

Abstract

Objective: Reaction time is shortened when a startling acoustic stimulus (SAS) is delivered together with the 'go' signal in normal subjects and patients with Parkinson's disease (IPD), but not in patients with progressive supranuclear palsy (PSP). Similar shortening of reaction time has been reported in normal subjects and patients with IPD with transcranial magnetic stimulation (TMS). In this paper, we analyzed the effect of TMS on reaction time in patients with PSP. Methods: Six patients with PSP received the instruction to extend the wrist to a visual cue. In test trials, the visual signal was accompanied by either a SAS or a subthreshold TMS applied to the motor area. The same experimental paradigm was applied to 7 patients with IPD, and 10 normal subjects. We measured both reaction time and the slope of the initial accelerometric displacement (SAD). Results: Neither TMS nor SAS changed significantly reaction time in PSP patients. This observation was in contrast with the marked reaction time shortening induced by both stimuli in a similar amount in normal subjects and patients with IPD. Furthermore, SAS and TMS did not modify the SAD in PSP, but shortened it significantly in IPD. Conclusion: The absence of an effect of TMS and SAS on reaction time in PSP patients suggests that these patients have a dysfunction in the mechanisms of facilitation of reaction time. The fact that TMS and SAS induced similar effects on reaction time in normal subjects, IPD and PSP patients indicate the possibility of common mechanisms of action for both types of stimuli. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 20/01/20 alle ore 22:11:10