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Titolo:
Ipsilateral activation of the unaffected motor cortex in patients with hemiparetic stroke
Autore:
Caramia, MD; Palmieri, MG; Giacomini, P; Iani, C; Dally, L; Silvestrini, M;
Indirizzi:
Univ Roma Tor Vergata, Neurol Clin, Dipartimento Neurosci, I-00144 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00144 o Neurosci, I-00144 Rome, Italy IRCSS S Lucia, Rome, Italy IRCSS S Lucia Rome ItalyIRCSS S Lucia, Rome, Italy Univ Rome La Sapienza, Clin Malattie Nervose & Mentali, Rome, Italy Univ Rome La Sapienza Rome Italy alattie Nervose & Mentali, Rome, Italy
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 11, volume: 111, anno: 2000,
pagine: 1990 - 1996
SICI:
1388-2457(200011)111:11<1990:IAOTUM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC STIMULATION; CORTICOSPINAL PROJECTIONS; FUNCTIONAL REORGANIZATION; POSTSTROKE HEMIPARESIS; TRANSCRANIAL DOPPLER; EVOKED-POTENTIALS; RECOVERY; INFARCTION; AREAS; INVOLVEMENT;
Keywords:
transcranial magnetic stimulation; motor evoked potentials; transcranial Doppler; stroke; neuronal plasticity; ipsilateral task performance; functional recovery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Caramia, MD Univ Roma Tor Vergata, Osp S Eugenio, Neurol Clin, Piazzale Umanesimo 10, I-00144 Rome, Italy Univ Roma Tor Vergata Piazzale Umanesimo 10Rome Italy I-00144
Citazione:
M.D. Caramia et al., "Ipsilateral activation of the unaffected motor cortex in patients with hemiparetic stroke", CLIN NEU, 111(11), 2000, pp. 1990-1996

Abstract

Background and purpose: Recent research has shown that following stroke patients can display ipsilateral activity reflecting a functional link between the undamaged hemisphere and the affected upper limb on the same side of the body. In the present study the capacity for ipsilateral activation is documented during recovery by using transcranial magnetic stimulation (TMS) and transcranial Doppler (TCD). Methods: Fourteen patients affected by hemispheric stroke were examined with TMS and TCD within 48 h of onset, and again 6 months later. Neurologicalsigns were scored with reference to the NIHSS, and patients executed a thumb to finger opposition task so as to further estimate the motor deficit. Twenty healthy volunteers represented the control population. Results: (1) Both TMS and TCD yielded homogeneous results showing ipsilateral activity between affected hands and undamaged hemispheres. On stimulating the motor cortex 3 cm anterior and 3 cm lateral to Ct, a scalp site remote from the primary motor area, ipsilateral, motor evoked potentials (iMEPs) from hand muscles were found in recovered patients. (2) In 8 controls iMEPs with smaller amplitudes than patients could be obtained by stimulating only the left hemisphere. (3) TCD revealed increased blood flow velocity in the ipsilateral:MCA by activating the recovering hand (10.5 +/- 3.3%; P < 0.001). Conclusion: TM reveals a specific area in the motor cortex from which ipsilateral MEPs can be elicited and both TMS and TCD indicate that an ipsilateral corticospinal tract can be accessible in some adult controls or becomesunmasked after cerebral damage. (C) 2000 Elsevier Science Ireland Ltd. Allrights reserved.

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Documento generato il 03/07/20 alle ore 15:48:41