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Titolo:
Changes in absorptive function of rat intestine injured by methotrexate
Autore:
Naruhashi, K; Nadai, M; Nakao, M; Suzuki, N; Nabeshima, T; Hasegawa, T;
Indirizzi:
Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Higashi Ku, Nagoya, Aichi 4618673, Japan Nagoya Univ Nagoya Aichi Japan 4618673 i Ku, Nagoya, Aichi 4618673, Japan Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Meijo Univ, Fac Pharm, Nagoya, Aichi 468, Japan Meijo Univ Nagoya Aichi Japan 468 iv, Fac Pharm, Nagoya, Aichi 468, Japan Nagoya Univ, Sch Med, Dept Hosp Pharm, Nagoya, Aichi 466, Japan Nagoya Univ Nagoya Aichi Japan 466 t Hosp Pharm, Nagoya, Aichi 466, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 12, volume: 27, anno: 2000,
pagine: 980 - 986
SICI:
0305-1870(200012)27:12<980:CIAFOR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL COLITIS; DIAMINE OXIDASE; PERMEABILITY; TRANSPORTER; INVITRO; DRUGS;
Keywords:
absorptive function of the intestine; acute injury; cephalexin; histopathological examination; intestinal peptide transporter; methotrexate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hasegawa, T Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan Nagoya Univ 1-1-20 Daikominami Nagoya Aichi Japan 4618673 apan
Citazione:
K. Naruhashi et al., "Changes in absorptive function of rat intestine injured by methotrexate", CLIN EXP PH, 27(12), 2000, pp. 980-986

Abstract

1. Methotrexate (MTX), an anticancer drug, has been shown to induce acute injury in the small intestine. The present study was designed to investigate the in vivo absorptive function of the small intestine injured by MTX using an amino-beta -lactam antibiotic cephalexin (CEX). Time-dependent changes in diamine oxidase (DAO) and alkaline phosphatase (ALP) activity in the small intestine and histopathological findings were also measured in rats treated with MTX (20 mg/kg).2. Most severe mucosal damage was observed 2 days after MTX treatment and the area under the plasma concentration-time curve of CEX (AUC(CEX)) following oral administration of 20 mg/kg tended to decrease. Thereafter, the AUC(CEX) increased significantly and the histopathological changes diminished within 5 days.3. Both villus height and mucosal weight followed the same pattern, decreasing in the first 2 or 3 days following treatment, increasing on the 5th day and returning to control levels by the 10th day. Methotrexate-induced changes in the mucosal wet weight/whole intestinal weight ratio were significantly correlated with those of AUC(CEX), but did not correlate with mucosal DAO and ALP activity.4. These findings provide evidence that the change in the total amount of CEX is an index of the active transport function, probably by intestinal peptide transporter (PEPT1), and is well reflected by histopathological changes in the intestinal mucosa induced by MTX. In addition, there is a possibility that this method could be applied in the clinical setting for diagnosis of intestinal status and absorptive function.

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Documento generato il 07/04/20 alle ore 03:02:52