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Titolo:
Epicardial outgrowth inhibition leads to compensatory mesothelial outflow tract collar and abnormal cardiac septation and coronary formation
Autore:
Gittenberger-de Groot, AC; Peeters, MPFMV; Bergwerff, M; Mentink, MMT; Poelmann, RE;
Indirizzi:
Leiden Univ, Med Ctr, Dept Anat & Embryol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands
Titolo Testata:
CIRCULATION RESEARCH
fascicolo: 11, volume: 87, anno: 2000,
pagine: 969 - 971
SICI:
0009-7330(20001124)87:11<969:EOILTC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; HEART; CELLS; DIFFERENTIATION; FIBROBLASTS; CONTRIBUTE; ARTERIES; EMBRYO;
Keywords:
epicardium; coronary vasculature; myocardial differentiation; ablation; chimerization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Gittenberger-de Groot, AC Leiden Univ, Med Ctr, Dept Anat & Embryol, POB 9602, NL-2300 RC Leiden, Netherlands Leiden Univ POB 9602 Leiden Netherlands NL-2300 RC
Citazione:
A.C. Gittenberger-de Groot et al., "Epicardial outgrowth inhibition leads to compensatory mesothelial outflow tract collar and abnormal cardiac septation and coronary formation", CIRCUL RES, 87(11), 2000, pp. 969-971

Abstract

In the present study, we investigated the modulatory role of the epicardium in myocardial and coronary development. Epicardial cell tracing experiments have shown that epicardium-derived cells are the source of interstitial myocardial fibroblasts, cushion mesenchyme, and smooth muscle cells. Epicardial outgrowth inhibition studies show abnormalities of the compact myocardial layer, myocardialization of cushion tissue, looping, septation, and coronary vascular formation. Lack of epicardial spreading is partly compensated by mesothelial outgrowth over the conotruncal region, Heterospecific epicardial transplant is able to partially rescue the myocardial development, as well as septation and coronary formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:25:44