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Titolo:
Regional size reduction in the human corpus callosum following pre- and perinatal brain injury
Autore:
Moses, P; Courchesne, E; Stiles, J; Trauner, D; Egaas, B; Edwards, E;
Indirizzi:
Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 it Sci, La Jolla, CA 92093 USA Childrens Hosp, Res Ctr, Lab Res Neurosci Autism, San Diego, CA 92123 USA Childrens Hosp San Diego CA USA 92123 sci Autism, San Diego, CA 92123 USA Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 12, volume: 10, anno: 2000,
pagine: 1200 - 1210
SICI:
1047-3211(200012)10:12<1200:RSRITH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL RHESUS-MONKEY; PROJECTION NEURONS; POSTNATAL-DEVELOPMENT; ONTOGENETIC CHANGE; POSTCENTRAL GYRUS; CONNECTIONS; MORPHOLOGY; TOPOGRAPHY; CHILDHOOD; CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Moses, P Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 a Jolla, CA 92093 USA
Citazione:
P. Moses et al., "Regional size reduction in the human corpus callosum following pre- and perinatal brain injury", CEREB CORT, 10(12), 2000, pp. 1200-1210

Abstract

This morphometric study examined two aspects of corpus callosum development: pediatric cortico-callosal topography and developmental neuroplasticity subsequent to perinatal brain injury. In vivo magnetic resonance imaging was used to quantify the total midsagittal cross-sectional area and five anterioposterior subregions of the callosum in 10 children with focal lesions and 86 healthy volunteer control subjects. Nine of the ten children with early injury showed a reduction in the total area of the callosum relative to matched controls. The area of the total callosum cross-section was inversely proportional to the size of lesion. All patients displayed region-specific size reduction. This regional thinning bore a topographical relationship to the lesion sites. Reduction in anterior subregions 1, 2 and 3 was respectively associated with lesions in the anterior inferior frontal area, the middle and superior frontal region, and the precentral area. Attenuation of subregion 4 corresponded to anterior parietal lesions, and thinning of subregion 5 occurred with posterior parietal injury. This cortical-callosal pattern coincides with adult and nonhuman primate mappings. Callosal thinning despite the early onset of the lesions suggests limits to developmental neuroplasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 16:01:40