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Titolo:
Hematologic dyscrasia associated with ticlopidine therapy: evidence for causality
Autore:
Paradiso-Hardy, FL; Angelo, CM; Lanctot, KL; Cohen, EA;
Indirizzi:
Sunnybrook & Womens Coll, Hlth Sci Ctr, Dept Pharm, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll Toronto ON Canada M4N 3M5 to, ON M4N 3M5, Canada Sunnybrook & Womens Coll, Hlth Sci Ctr, Div Cardiol, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll Toronto ON Canada M4N 3M5 to, ON M4N 3M5, Canada Sunnybrook & Womens Coll, Hlth Sci Ctr, Div Clin Pharmacol, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll Toronto ON Canada M4N 3M5 to, ON M4N 3M5, Canada Univ Toronto, Fac Pharm, Toronto, ON, Canada Univ Toronto Toronto ON Canada v Toronto, Fac Pharm, Toronto, ON, Canada Sunnybrook & Womens Coll, Hlth Sci Ctr, HOPE Res Ctr, Div Clin Pharmacol, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll Toronto ON Canada M4N3M5 to, ON M4N 3M5, Canada Sunnybrook & Womens Coll, Hlth Sci Ctr, Dept Psychiat, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll Toronto ON Canada M4N 3M5 to, ON M4N 3M5, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto, Dept Pharmacol, Toronto, ON, Canada Univ Toronto Toronto ONCanada onto, Dept Pharmacol, Toronto, ON, Canada Sunnybrook & Womens Coll, Hlth Sci Ctr, Div Cardiol, Dept Med, Toronto, ONM4N 3M5, Canada Sunnybrook & Womens Coll Toronto ON Canada M4N 3M5 nto, ONM4N 3M5, Canada
Titolo Testata:
CANADIAN MEDICAL ASSOCIATION JOURNAL
fascicolo: 11, volume: 163, anno: 2000,
pagine: 1441 - 1448
SICI:
0820-3946(20001128)163:11<1441:HDAWTT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
THROMBOTIC THROMBOCYTOPENIC PURPURA; SEVERE APLASTIC-ANEMIA; COLONY-STIMULATING FACTOR; ADVERSE DRUG-REACTIONS; INTRACORONARY STENT PLACEMENT; CORONARY-ARTERY STENTS; HIGH-RISK PATIENTS; INDUCED AGRANULOCYTOSIS; ANTIPLATELET THERAPY; INDUCED NEUTROPENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Paradiso-Hardy, FL Sunnybrook & Womens Coll, Hlth Sci Ctr, Dept Pharm, 2075 Bayview Ave,Room E300, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll 2075 Bayview Ave,Room E300 Toronto ON Canada M4N 3M5
Citazione:
F.L. Paradiso-Hardy et al., "Hematologic dyscrasia associated with ticlopidine therapy: evidence for causality", CAN MED A J, 163(11), 2000, pp. 1441-1448

Abstract

Background: Several rare, potentially fatal types of hematologic dyscrasia, such as agranulocytosis, aplastic anemia, neutropenia, pancytopenia, thrombocytopenia and thrombotic thrombocytopenic purpura (TTP), have been associated with ticlopidine therapy. The extent to which ticlopidine is the causative factor has not been addressed quantitatively. Methods: We identified 211 published case reports of hematologic dyscrasiaassociated with ticlopidine therapy from a MEDLINE search. We analyzed the91 reports that could be evaluated, using the Bayesian Adverse Reaction Diagnostic Instrument to calculate the posterior probability that ticlopidinecaused the hematologic dyscrasia based on epidemiologic and clinical trialdata (prior odds) and case information (likelihood ratio). Results: The median posterior probability values (and range) for agranulocytosis, aplastic anemia, neutropenia, pancytopenia, thrombocytopenia and TTP were 0.95 (0.53-0.98), 0.81 (0.57-0.93), 0.86 (0.75-0.96), 0.78 (0.61-0.89), 0.74 (0-0.92) and 1.0 (0.33-1.00) respectively. The posterior probability was 0.75 or greater in 82 (90%) of the case reports. Interpretation: This systematic analysis provides stronger evidence to implicate ticlopidine as the causative factor in the various types of hematologic dyscrasia in most published case reports.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:39:26