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Titolo:
Risk factors for development of post-trabeculectomy endophthalmitis
Autore:
Lehmann, OJ; Bunce, C; Matheson, MM; Maurino, V; Khaw, PT; Wormald, R; Barton, K;
Indirizzi:
Inst Ophthalmol, Dept Mol Genet, London EC1V 9EL, England Inst OphthalmolLondon England EC1V 9EL Genet, London EC1V 9EL, England Moorfields Eye Hosp, Glaucoma Serv, London, England Moorfields Eye Hosp London England Hosp, Glaucoma Serv, London, England Moorfields Eye Hosp, Glaxo Dept Ophthalm Epidemiol, London, England Moorfields Eye Hosp London England Ophthalm Epidemiol, London, England Univ Coll London, Dept Pathol, Inst Ophthalmol, London WC1E 6BT, England Univ Coll London London England WC1E 6BT almol, London WC1E 6BT, England
Titolo Testata:
BRITISH JOURNAL OF OPHTHALMOLOGY
fascicolo: 12, volume: 84, anno: 2000,
pagine: 1349 - 1353
SICI:
0007-1161(200012)84:12<1349:RFFDOP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLEB-RELATED ENDOPHTHALMITIS; GLAUCOMA-FILTERING SURGERY; ADJUNCTIVE MITOMYCIN-C; INFECTION; 5-FLUOROURACIL; HYPOTONY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lehmann, OJ Inst Ophthalmol, Dept Mol Genet, Bath St, London EC1V 9EL, England Inst Ophthalmol Bath St London England EC1V 9EL 9EL, England
Citazione:
O.J. Lehmann et al., "Risk factors for development of post-trabeculectomy endophthalmitis", BR J OPHTH, 84(12), 2000, pp. 1349-1353

Abstract

Background/aims-Although adjunctive use of antiproliferative agents improves the success rate of glaucoma filtration surgery it profoundly alters themorphology of the filtering bleb. In view of these structural changes, which have been suggested to predispose to bleb infection, the relative importance of potential risk factors in the development or posttrabeculectomy endophthalmitis was investigated. Methods-A case-control study was performed on patients with posttrabeculectomy endophthalmitis presenting to a single academic centre over a 61/2 year period. Cases were diagnosed by the combination of vitreous and aqueous inflammation occurring 4 or more weeks postoperatively with control patientschosen by selecting the three patients undergoing trabeculectomy immediately following each index case. Results-Analysis of these data, derived from 23 cases and 69 controls, demonstrated that an episode of blebitis and the presence of diabetes mellituswere statistically significantly associated with subsequent endophthalmitis (odds ratios (OR) 11.8, 95% CI: 2.21-88.31, p = 0.003 and OR 4.51, 95 % CI 1.02-20.29, p = 0.04 respectively). The data also suggest arn associationexists between antiproliferative use and endophthalmitis (OR 3.3, 95% CI 0.95-15.19, p = 0.07) as the time interval between filtration surgery and development of endophthalmitis was significantly shorter in patients treated with antiproliferative agents (p = 0.001). Conclusions-These results provide strong evidence of an increased risk of late endophthalmitis in patients who have diabetes mellitus or have had an episode of blebitis and suggest antiproliferative agents may also have an important role.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:07:43