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Titolo:
Pharmacokinetics of verapamil in New Zealand white rabbits during ontogeny
Autore:
Solans, C; Bregante, MA; Aramayona, JJ; Fraile, LJ; Garcia, MA;
Indirizzi:
Univ Zaragoza, Fac Vet Sci, Dept Pharmacol & Physiol, E-50013 Zaragoza, Spain Univ Zaragoza Zaragoza Spain E-50013 & Physiol, E-50013 Zaragoza, Spain Univ Zaragoza, Fac Vet Sci, Dept Analyt Chem, E-50013 Zaragoza, Spain UnivZaragoza Zaragoza Spain E-50013 nalyt Chem, E-50013 Zaragoza, Spain
Titolo Testata:
BIOLOGY OF THE NEONATE
fascicolo: 4, volume: 78, anno: 2000,
pagine: 321 - 326
SICI:
0006-3126(2000)78:4<321:POVINZ>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-METABOLIZING-ENZYMES; PLASMA-PROTEIN BINDING; CHILDREN; DILTIAZEM; KINETICS; HUMANS; LIVER;
Keywords:
pharmacokinetics; ontogeny; verapamil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Bregante, MA Univ Zaragoza, Fac Vet Sci, Dept Pharmacol & Physiol, Miguel Servet 177, E-50013 Zaragoza, Spain Univ Zaragoza Miguel Servet 177 Zaragoza Spain E-50013 Spain
Citazione:
C. Solans et al., "Pharmacokinetics of verapamil in New Zealand white rabbits during ontogeny", BIOL NEONAT, 78(4), 2000, pp. 321-326

Abstract

The pharmacokinetics of verapamil during ontogeny in rabbits and in vitro verapamil demethylase activity have been investigated in the liver and whole blood. In vivo experiments revealed that the slope of the postdistributive phase as well as the area under the curve and clearance showed significant differences when newborn and adult rabbits were compared. Other pharmacokinetic parameters, such as volume of distribution and plasma protein binding did not show any statistical differences. Liver microsomal preparation samples from 1-, 8- and 16-day-old rabbits displayed approximately 20% of theactivity observed in adults. A significant verapamil demethylase activity in the whole blood of rabbits was also noted. The in vivo results show thatnewborn rabbits have a capacity to eliminate verapamil that is similar or even higher than that of adults. These findings could not be explained withregard to the in vitro liver metabolism of verapamil, although they could with respect to blood metabolism. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:03:24