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Titolo:
Altered fetal pituitary-adrenal function in the ovine fetus treated with RU486 and meloxicam, an inhibitor of prostaglandin synthase-II
Autore:
McKeown, KJ; Challis, JRG; Small, C; Adamson, L; Bocking, AD; Fraser, M; Rurak, D; Riggs, KW; Lye, SJ;
Indirizzi:
Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 ysiol, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Obstet & Gynecol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 necol, Toronto, ON M5S 1A8, Canada Univ Toronto, MRC, Grp Fetal & Neonatal Hlth & Dev, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 & Dev, Toronto, ON M5S 1A8, Canada Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Univ Western Ontario, London, ON N6A 5B8, Canada Univ Western Ontario London ON Canada N6A 5B8 London, ON N6A 5B8, Canada Lawson Res Inst, London, ON N6A 5B8, Canada Lawson Res Inst London ON Canada N6A 5B8 Inst, London, ON N6A 5B8, Canada Univ British Columbia, MRC, Grp Dev & Fetal Hlth, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 6, volume: 63, anno: 2000,
pagine: 1899 - 1904
SICI:
0006-3363(200012)63:6<1899:AFPFIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE-GESTATION; PRETERM LABOR; DUCTUS-ARTERIOSUS; PREMATURE LABOR; H SYNTHASE-1; SHEEP; INDOMETHACIN; ADRENOCORTICOTROPIN; EXPRESSION; INCREASE;
Keywords:
ACTH; cortisol; parturition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: McKeown, KJ Univ Toronto, Dept Physiol, Med Sci Bldg,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Univ Toronto Med Sci Bldg,1 Kings Coll Circle Toronto ON Canada M5S 1A8
Citazione:
K.J. McKeown et al., "Altered fetal pituitary-adrenal function in the ovine fetus treated with RU486 and meloxicam, an inhibitor of prostaglandin synthase-II", BIOL REPROD, 63(6), 2000, pp. 1899-1904

Abstract

Term and preterm labor are associated with increased fetal hypothalamic-pituitary-adrenal (HPA) activation and synthesis of prostaglandins (PGs) generated through the increased expression of prostaglandin Fl synthase-ll (PGHS-II) in the placenta. Inhibition of PGHS-II has been advocated as a means of producing uterine tocolysis, but the effects of such treatment on fetal endocrine functions have not been thoroughly examined. Because PGE(2) is known to activate the fetal HPA axis, we hypothesized that administration of meloxicam, a PGHS-II inhibitor, to sheep in induced labor would suppress fetal HPA function. Chronically catheterized pregnant ewes were treated with RU486, a progesterone receptor antagonist, to produce active labor, and then treated with either high-maintenance-dose meloxicam, graded-maintenance-dose meloxicam, or a saline infusion. Maternal uterine contraction frequencyincreased 24 h after the RU486 injection and the animals were in active labor by 48 +/- 4 h. RU486 injection led to increased concentrations of PGE(2), ACTH, and cortisol in the fetal circulation, and increased concentrations of 13,14 dihydro 15-ketoprostaglandin F-2 alpha (PGFM) in the maternal circulation. Uterine activity was inhibited within 12 h of beginning meloxicam infusion at both infusion regimes. During meloxicam infusion there were significant decreases in fetal plasma PGE,, ACTH, and cortisol concentrations, and PGFM concentrations in maternal plasma. In control animals, frequency of uterine contractions, maternal plasma PGFM, fetal plasma PGE,, ACTH, and cortisol concentrations increased after RU486 administration, and continued to rise during saline infusion until delivery occurred. We conclude that RU486-provoked labor in sheep is associated with activation of fetal HPA function, and that this is attenuated during meloxicam treatment to a levelconsidered compatible with pregnancy maintenance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:44:40