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Titolo:
Detection of multiple bone morphogenetic protein messenger ribonucleic acids and their signal transducer, Smad1, during mouse decidualization
Autore:
Ying, Y; Zhao, GQ;
Indirizzi:
Univ Missouri, Coll Vet Med, Dept Pathobiol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ept Pathobiol, Columbia, MO 65211 USA
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 6, volume: 63, anno: 2000,
pagine: 1781 - 1786
SICI:
0006-3363(200012)63:6<1781:DOMBMP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; MICE DEFICIENT; RECEPTOR; SPERMATOGENESIS; IMPLANTATION; ANGIOGENESIS; MAINTENANCE; EXPRESSION; EMBRYO; PLAYS;
Keywords:
decidua; growth factors; implantation/early development; signal transduction; uterus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, GQ Univ Missouri, Coll Vet Med, Dept Pathobiol, 209C Connaway Hall, Columbia,MO 65211 USA Univ Missouri 209C Connaway Hall Columbia MO USA 65211 65211 USA
Citazione:
Y. Ying e G.Q. Zhao, "Detection of multiple bone morphogenetic protein messenger ribonucleic acids and their signal transducer, Smad1, during mouse decidualization", BIOL REPROD, 63(6), 2000, pp. 1781-1786

Abstract

Decidualization is a process characterized by morphological and functionalchanges in the uterine stromal cells. In addition to steroid hormones, growth factors are implicated in this process. Using in situ hybridization, wefound that mRNAs for several bone morphogenetic proteins (BMPs) were detected in the decidual and vascular endothelial cells. The Bmp7 mRNA was detected in the decidualizing stromal cells surrounding the blastocyst and distributed in a gradient, with the highest levels occurring near the uterine epithelium at 4.5 days post-coitus (dpc). With the progression of decidualization, Bmp7 signals in the deciduum at the antimesometrial side decreased, but strong signals were retained in the decidual area at the mesometrial side at 7.0 dpc. In contrast, Bmp8a transcripts increased from 5.5 to 7.0 dpc in the decidual tissue, with the highest levels occurring in the secondary decidual zone at the antimesometrial side. The Bmp2, Bmp4 and Smad1 transcripts were found in the secondary decidual zone, especially at the mesometrial side. The Bmp2 signals were primarily detected in decidual cells, whereas Bmp4 and Smad1 transcripts were mainly detected in vascular endothelial cells, suggesting that they may be involved in decidual angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 09:13:34