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Titolo:
Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) graftsand their ability to encapsulate anticancer drugs
Autore:
Kojima, C; Kono, K; Maruyama, K; Takagishi, T;
Indirizzi:
Univ Osaka Prefecture, Grad Sch Engn, Dept Appl Mat Sci, Sakai, Osaka 5998531, Japan Univ Osaka Prefecture Sakai Osaka Japan 5998531 kai, Osaka 5998531, Japan Univ Osaka Prefecture, Res Inst Adv Sci & Technol, Dept Appl Biosci, Sakai, Osaka 5998570, Japan Univ Osaka Prefecture Sakai Osaka Japan 5998570 kai, Osaka 5998570, Japan Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 1990195, Japan Teikyo Univ Sagamiko Kanagawa Japan 1990195 miko, Kanagawa 1990195, Japan
Titolo Testata:
BIOCONJUGATE CHEMISTRY
fascicolo: 6, volume: 11, anno: 2000,
pagine: 910 - 917
SICI:
1043-1802(200011/12)11:6<910:SOPDHP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC MACROMOLECULES; POLYETHYLENE-GLYCOL; MOLECULAR ARCHITECTURE; STARBURST DENDRIMERS; COVALENT ATTACHMENT; POLYMERS; RELEASE; LIPOSOMES; CHEMISTRY; MICELLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kono, K Univ Osaka Prefecture, Grad Sch Engn, Dept Appl Mat Sci, 1-1 Gakuen Cho, Sakai, Osaka 5998531, Japan Univ Osaka Prefecture 1-1 Gakuen Cho Sakai Osaka Japan 5998531 pan
Citazione:
C. Kojima et al., "Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) graftsand their ability to encapsulate anticancer drugs", BIOCONJ CHE, 11(6), 2000, pp. 910-917

Abstract

Polyamidoamine dendrimers having poly(ethylene glycol) grafts were designed as a novel drug carrier which possesses an interior for the encapsulationof drags and a biocompatible surface. Poly(ethylene glycol) monomethyl ether with the average molecular weight of 550 or 2000 was combined to essentially every chain end of the dendrimer of the third or fourth generation viaurethane bond. The poly(ethylene glycol)-attached dendrimers encapsulatinganticancer drugs, adriamycin and methotrexate, were prepared by extractionwith chloroform from mixtures of the poly(ethylene glycol)-attached dendrimers and varying amounts of the drugs. Their ability to encapsulate these drugs increased with increasing dendrimer generation and chain length of poly(ethylene glycol) grafts, Among the poly(ethylene glycol)-attached dendrimers prepared, the highest ability was achieved by the dendrimer of the fourth generation having the poly(ethylene glycol) grafts with the average molecular weight of 2000, which could retain 6.5 adriamycin molecules or 26 methotrexate molecules/dendrimer molecule. The methotrexate-loaded poly(ethylene glycol)-attached dendrimers released the drug slowly in an aqueous solution of low ionic strength. However, in isotonic solutions, methotrexate andadriamycin were readily released from the poly(ethylene glycol)-attached dendrimers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 00:20:51