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Titolo:
Apolipoprotein D
Autore:
Rassart, E; Bedirian, A; Do Carmo, S; Guinard, O; Sirois, J; Terrisse, L; Milne, R;
Indirizzi:
Univ Quebec, Dept Sci Biol, Montreal, PQ H3C 3P8, Canada Univ Quebec Montreal PQ Canada H3C 3P8 Biol, Montreal, PQ H3C 3P8, Canada Univ Ottawa, Inst Heart, Lipoprot & Atherosclerosis Grp, Ottawa, ON K1Y 4E9, Canada Univ Ottawa Ottawa ON Canada K1Y 4E9 osis Grp, Ottawa, ON K1Y 4E9, Canada
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
fascicolo: 1-2, volume: 1482, anno: 2000,
pagine: 185 - 198
SICI:
0167-4838(20001018)1482:1-2<185:AD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER CELLS; GROSS CYSTIC-DISEASE; NIEMANN-PICK-DISEASE; D MESSENGER-RNA; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; D GENE; HUMAN-PLASMA; TISSUE DISTRIBUTION; PERIPHERAL-NERVE; A-I;
Keywords:
apolipoprotein D; GCDFP-24; neurodegenerative disease; Alzheimer's disease; Niemann-Pick disease; regeneration; reinnervation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Rassart, E Univ Quebec, Dept Sci Biol, CP 8888, Montreal, PQ H3C 3P8, Canada Univ Quebec CP 8888 Montreal PQ Canada H3C 3P8 H3C 3P8, Canada
Citazione:
E. Rassart et al., "Apolipoprotein D", BBA-PROT ST, 1482(1-2), 2000, pp. 185-198

Abstract

Apolipoprotein D (apoD) is a 29-kDa glycoprotein that is primarily associated with high density lipoproteins in human plasma. It is an atypical apolipoprotein and, based on its primary structure, apoD is predicted to be a member of the lipocalin family. Lipocalins adopt a beta -barrel tertiary structure and transport small hydrophobic ligands. Although apoD can bind cholesterol, progesterone, pregnenolone, bilirubin and arachidonic acid, it is unclear if any, or all of these, represent its physiological ligands. The apoD gene is expressed in many tissues, with high levels of expression in spleen, testes and brain. ApoD is present at high concentrations in the cyst fluid of women with gross cystic disease of the breast, a condition associated with increased risk of breast cancer. It also accumulates at sites of regenerating peripheral nerves and in the cerebrospinal fluid of patients with neurodegenerative conditions, such as Alzheimer's disease. ApoD may, therefore, participate in maintenance and repair within the central and peripheral nervous systems. While its role in metabolism has yet to be defined, apoD is likely to be a multi-ligand, multi-functional transporter. It could transport a ligand from one cell to another within an organ, scavenge a ligand within an organ for transport to the blood or could transport a ligand from the circulation to specific cells within a tissue. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:58:53