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Titolo:
Amphibian choroid plexus lipocalin, Cp11
Autore:
Lepperdinger, G;
Indirizzi:
Austrian Acad Sci, Inst Mol Biol, A-5020 Salzburg, Austria Austrian Acad Sci Salzburg Austria A-5020 Biol, A-5020 Salzburg, Austria
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
fascicolo: 1-2, volume: 1482, anno: 2000,
pagine: 119 - 126
SICI:
0167-4838(20001018)1482:1-2<119:ACPLC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOL-BINDING-PROTEIN; PROSTAGLANDIN-D SYNTHASE; CENTRAL-NERVOUS-SYSTEM; INDUCED NEURAL TISSUE; XENOPUS-LAEVIS; 9-CIS-RETINOIC ACID; GENE-EXPRESSION; DEFICIENT MICE; MODEL SYSTEM; TRANSTHYRETIN;
Keywords:
retinoid binding lipocalin; retinoic acid; choroid plexus; embryogenesis; prostaglandin synthase; transthyretin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Lepperdinger, G Austrian Acad Sci, Inst Mol Biol, Billrothstr 11, A-5020 Salzburg, Austria Austrian Acad Sci Billrothstr 11 Salzburg Austria A-5020
Citazione:
G. Lepperdinger, "Amphibian choroid plexus lipocalin, Cp11", BBA-PROT ST, 1482(1-2), 2000, pp. 119-126

Abstract

Choroid plexus lipocalin 1 (Cpl1) has been isolated from the African clawed toad (Xenopus laevis) and the cane toad (Bufo marinus). Xcpl1 has been used as a marker for studying early neural development. Due to its retinoid binding properties and the fact that it causes dysmorphogenesis when overexpressed in the early embryo, the protein product is considered to be part ofthe retinoic acid signalling pathway. Later in development and during adulthood, the epithelial cell sheet of the choroid plexus which forms the blood-cerebrospinal fluid barrier expresses cpl1 as the predominant secretory protein. These data, the similarity of Cpl1 to prostaglandin D-2 synthase and its functional homology to transthyretin will be discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:06:01