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Titolo: The lipocalin protein family: structural and sequence overview
Autore: Flower, DR; North, ACT; Sansom, CE;
- Indirizzi:
- Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England Edward Jenner Inst Vaccine Res Newbury Berks England RG20 7NN ks, England Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England Univ London Birkbeck Coll, Dept Crystallog, London WC1E 7HX, England Univ London Birkbeck Coll London England WC1E 7HX ndon WC1E 7HX, England
- Titolo Testata:
- BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
fascicolo: 1-2,
volume: 1482,
anno: 2000,
pagine: 9 - 24
- SICI:
- 0167-4838(20001018)1482:1-2<9:TLPFSA>2.0.ZU;2-4
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- X-RAY CRYSTALLOGRAPHY; BINDING-PROTEIN; MOLECULAR-STRUCTURE; CRYSTAL-STRUCTURE; 3-DIMENSIONAL STRUCTURE; ANGSTROM RESOLUTION; DATABASE; DOMAIN; SITE; SUPERFAMILY;
- Keywords:
- lipocalin; fatty acid binding protein; avidin; structural comparison; characteristic motif; protein superfamily;
- Tipo documento:
- Review
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 58
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Flower, DR Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England Edward Jenner Inst Vaccine Res Newbury Berks England RG20 7NN
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- Citazione:
- D.R. Flower et al., "The lipocalin protein family: structural and sequence overview", BBA-PROT ST, 1482(1-2), 2000, pp. 9-24
Abstract
Lipocalins are remarkably diverse at the sequence level yet have highly conserved structures. Most lipocalins share three characteristic conserved sequence motifs - the kernel lipocalins - while others are more divergent family members - the outlier lipocalins - typically sharing only one or two. This classification is a useful tool for analysing the family, and within these large sets are smaller groups sharing much higher levels of sequence similarity. The lipocalins are also part of a larger protein superfamily: thecalycins, which includes the fatty acid binding proteins, avidins, a groupof metalloproteinase inhibitors, and triabin. The superfamily is characterised by a similar structure (a repeated +1 topology beta -barrel) and by the conservation of a remarkable structural signature. (C) 2000 Elsevier Science B.V. All rights reserved.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:15:16