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Titolo:
Adenovirus-mediated hepatocyte growth factor gene transfer prevents lethalliver failure in rats
Autore:
Nomi, T; Shiota, G; Isono, M; Sato, K; Kawasaki, H;
Indirizzi:
Tottori Univ, Fac Med, Dept Internal Med 2, Yonago, Tottori 6838504, JapanTottori Univ Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan Tottori Univ, Fac Med, Dept Mol Biol, Yonago, Tottori 6838504, Japan Tottori Univ Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 278, anno: 2000,
pagine: 338 - 343
SICI:
0006-291X(20001119)278:2<338:AHGFGT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; GALACTOSAMINE-SENSITIZED MICE; STAPHYLOCOCCAL-ENTEROTOXIN-B; FULMINANT HEPATIC-FAILURE; DISEASES; INJURY; SERUM; ACTIVATION; ENDOTOXIN; APOPTOSIS;
Keywords:
hepatocyte growth factor; gene transfer; liver failure; antiapoptotic effect; Bcl-xL; Cox-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Shiota, G Tottori Univ, Fac Med, Dept Internal Med 2, Yonago, Tottori 6838504, Japan Tottori Univ Yonago Tottori Japan 6838504 ottori 6838504, Japan
Citazione:
T. Nomi et al., "Adenovirus-mediated hepatocyte growth factor gene transfer prevents lethalliver failure in rats", BIOC BIOP R, 278(2), 2000, pp. 338-343

Abstract

Hepatocyte growth factor (HGF) has a potent anti-apoptotic effect on hepatocytes in D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-treated rats. Here, we report that adenovirus mediated HGF gene transfer into liver prevents liver failure and reduces mortality of rats treated with D-GalN/LPS. Fisher 344 rats, which were given intraperitoneal injections of pAxCAHGF 48 h before, were treated with D-GalN/LPS. Serum ALT in the HGF group at 6 and 12 h after D-GalN/LPS was decreased to 1/6 and 1/12 of the control group (P < 0.01, each). Concomitant reduction of apoptotic cells were also observed. The Kaplan-Meier analysis showed that a survival rate in the HGF group wasimproved, compared to that in the control group (P < 0.05). Caspase-3 activity in the HGF group decreased, compared to that in the control group, especially at 12 h (P < 0.05), although it maintained a high level in the control group. Expression of Bcl-xL and cyclooxygenase-2 (Cox-2) was induced inliver by HGF gene transfer. These data suggest that HGF exerts an antiapoptotic effect through dual induction of Bcl-xL and Cox-2, which suppresses caspase-3 activity. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:18:59