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Titolo:
Delayed effects of pyridostigmine and exercise training on acetylcholinesterase and muscle tension in mouse lower extremity
Autore:
Verma-Ahuja, S; Husain, K; Verhulst, S; Espinosa, JA; Somani, SM;
Indirizzi:
So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 acol, Springfield, IL 62794 USA So Illinois Univ, Sch Med, Dept Surg, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 Surg, Springfield, IL 62794 USA So Illinois Univ, Sch Med, Div Stat & Res Consulting, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 ting, Springfield, IL 62794 USA
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 9, volume: 74, anno: 2000,
pagine: 539 - 546
SICI:
0340-5761(200011)74:9<539:DEOPAE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ETHANOL INGESTION; RAT HINDLIMB MUSCLES; RECEPTOR; ADAPTATION; INCREASES; BROMIDE; SYSTEM; NERVE; ASSAY; SLOW;
Keywords:
pyridostigmine; exercise training; muscle tension; acetylcholinesterase; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Husain, K So Illinois Univ, Sch Med, Dept Pharmacol, POB 19629, Springfield, IL 62794 USA So Illinois Univ POB 19629 Springfield IL USA 62794 IL 62794 USA
Citazione:
S. Verma-Ahuja et al., "Delayed effects of pyridostigmine and exercise training on acetylcholinesterase and muscle tension in mouse lower extremity", ARCH TOXIC, 74(9), 2000, pp. 539-546

Abstract

In this study, the interactive effects of pyridostigmine, a pretreatment drug against nerve agents, and exercise training on muscle tension were investigated in the mouse lower extremity anterior muscular compartment by dorsiflexion of the foot with stimulation of the peroneal nerve. Acetylcholinesterase (AChE), lipid peroxidation (in terms of the end-product malondialdehyde, MDA) and creatine phosphokinase (CPK) activity in the muscle were correlated with muscle tension. Male NIH Swiss mice were divided into four groups and treated as follows: (1) sedentary control; (2) pyridostigmine (1.2 mg/kg orally) daily for the 5th and 6th weeks; (3) exercise training for 10 weeks; and (4) pyridostigmine plus exercise training for 10 weeks. Experiments on muscle tension were conducted 4 weeks after the last dose of pyridostigmine or saline and 24 h after exercise. The muscle tension was measured in right and left legs using a tension transduction device connected to a polygraph. After muscle tension recording, mice were killed, blood and triceps muscle were isolated, and plasma CPK and muscle AChE activities, and MDAwere determined. There was a significant increase in the muscle tension (P<0.05) in the group treated with pyridostigmine plus exercise as compared to the control and exercise groups. The pyridostigmine plus exercise group also showed a significant reduction in AChE activity (P < 0.01) and enhancedMDA (P < 0.05) in the triceps muscle. These results suggest that subchronic dosages of pyridostigmine and interaction with exercise training result in the delayed effects of reduction in muscle AChE activity and enhanced muscle tension.

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Documento generato il 07/07/20 alle ore 06:27:07