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Titolo:
Synthesis and analgesic activity of some quinazoline analogs of anpirtoline
Autore:
Radl, S; Hezky, P; Proska, J; Krejci, I;
Indirizzi:
Res Inst Pharm & Biochem, Prague 13060, Czech Republic Res Inst Pharm & Biochem Prague Czech Republic 13060 060, Czech Republic
Titolo Testata:
ARCHIV DER PHARMAZIE
fascicolo: 11, volume: 333, anno: 2000,
pagine: 381 - 386
SICI:
0365-6233(200011)333:11<381:SAAAOS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1A;
Keywords:
condensed anpirtoline analogs; quinoline derivatives; quinazoline derivatives; analgesic activity; 5-HT1A receptor ligands; 5-HT1B receptor ligands;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Radl, S Res Inst Pharm & Biochem, Kourimska 17, Prague 13060, Czech Republic Res Inst Pharm & Biochem Kourimska 17 Prague Czech Republic 13060
Citazione:
S. Radl et al., "Synthesis and analgesic activity of some quinazoline analogs of anpirtoline", ARCH PHARM, 333(11), 2000, pp. 381-386

Abstract

New condensed derivatives of anpirtoline, in which the pyridine ring is replaced with quinoline, quinazoline, 7-chloroquinoline, and 7-chloroquinazoline nuclei, have been synthesized. Their receptor binding profiles (5-HT1A,5-HT1B) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. The analgesic activity of compounds 4e-4g, and 4l are at least comparable to that of clinically used drugs flupirtine and tramadol under the same conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:12:15