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Titolo:
Assessment of chemosensitivity in patients with malignant bone and soft tissue tumors using thallium-201 scintigraphy and doxorubicin binding assay
Autore:
Murata, H; Kusuzaki, K; Takeshita, H; Hirata, M; Hashiguchi, S; Emoto, K; Ashihara, T; Hirasawa, Y;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Orthopaed Surg, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5C, volume: 20, anno: 2000,
pagine: 3967 - 3970
SICI:
0250-7005(200009/10)20:5C<3967:AOCIPW>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TL-201 SCINTIGRAPHY; HISTOLOGIC RESPONSE; ADRIAMYCIN BINDING; P-GLYCOPROTEIN; OSTEOSARCOMA; CHEMOTHERAPY; SARCOMA; ABILITY;
Keywords:
thallium-201 scintigraphy; doxorubicin binding assay; chemosensitivity; malignant bone and soft tissue tumors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Murata, H Kyoto Prefectural Univ Med, Dept Orthopaed Surg, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 6028566, Japan
Citazione:
H. Murata et al., "Assessment of chemosensitivity in patients with malignant bone and soft tissue tumors using thallium-201 scintigraphy and doxorubicin binding assay", ANTICANC R, 20(5C), 2000, pp. 3967-3970

Abstract

This study was performed to compare the accumulation of thallium (TI) -201which is correlated with malignancy and the doxorubicin binding ability, which is correlated with chemosensitivity, in nine patients who received preoperative chemotherapy with doxorubicin and cisplatin. (Tl)-201 scintigraphy was performed at 15 minutes (early image) and 3 hours (delayed image) after injection of 111 MBq of Tl-201. The change of degree of the radionuclideuptake between the early and delayed images was evaluated before and afterpreoperative chemotherapy. The doxorubicin binding ability (%DB) to nuclear DNA in living tumor cells isolated from biopsy materials was assessed by doxorubicin binding assay. The histologic response to preoperative chemotherapy was evaluated by the percentage of tumor necrosis. Before preoperativechemotherapy no changes of Tl-201 uptake between the early and delayed images was defected in any tumors. Five patients, who had no change of Tl-201 uptake after preoperative chemotherapy, showed a poor histologic response and had a %DB ranging from 10% to 70% (mean: 36.0%). The other four patients, who had a %DB greater than 90%, showed a good histologic response. All ofthese four patients had decreased Tl-201 uptake after preoperative chemotherapy. This study demonstrated that doxorubicin binding assay and midcourseTl-201 scintigraphy are useful methods to assess the response to chemotherapy early in malignant bone and soft tissue tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:37:38