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Titolo:
Evaluation of 8-hydroxydeoxyguanosine in human oral cells: The importance of tobacco smoke and urban environment
Autore:
Romano, G; Sgambato, A; Flamini, G; Boninsegna, A; Milito, S; Ardito, R; Cittadini, A;
Indirizzi:
Catholic Univ, Sch Med, Inst Gen Pathol, Giovanni XXIII Canc Res Ctr, I-00168 Rome, Italy Catholic Univ Rome Italy I-00168 XXIII Canc Res Ctr, I-00168 Rome, Italy Ctr Riferimento Oncol Basilicata, I-85028 RioneroIn Vuture, PZ, Italy Ctr Riferimento Oncol Basilicata RioneroIn Vuture PZ Italy I-85028 Italy
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5C, volume: 20, anno: 2000,
pagine: 3801 - 3805
SICI:
0250-7005(200009/10)20:5C<3801:EO8IHO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE-DNA-DAMAGE; DIESEL EXHAUST PARTICLES; CIGARETTE-SMOKING; HUMAN-LEUKOCYTES; REPAIR ACTIVITY; HUMAN LUNG; RAT-LIVER; 8-HYDROXYGUANINE; CARCINOGENESIS; CANCER;
Keywords:
adducts; 8-OHdG; cigarette smoke; molecular epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Romano, G Catholic Univ, Sch Med, Inst Gen Pathol, Giovanni XXIII Canc ResCtr, Lgo F Vito 1, I-00168 Rome, Italy Catholic Univ Lgo F Vito 1 Rome Italy I-00168 00168 Rome, Italy
Citazione:
G. Romano et al., "Evaluation of 8-hydroxydeoxyguanosine in human oral cells: The importance of tobacco smoke and urban environment", ANTICANC R, 20(5C), 2000, pp. 3801-3805

Abstract

The DNA adduct 8-hydroxydeoxyguanosine (8-OHdG) has been widely used as a sensitive biomarker for oxidative damage. To investigate the role of environmental factors on oxidative DNA damage formation the level of 8-OHdG was determined in oral cells from 109 healthy volunteers by an immunohistochemical method. A statistically significantly higher content of 8-OHdG was detected in oral cells from smokers (111+/-55, n=38) compared with non smokers (78+/-48, n=71), (p<0.01). Moreover; subjects living in an urban area showeda higher level of oxidative damage with respect to those living in a countryside-suburban ar ea (99+/-53, n=58 vs. 78+/-51, n=51), (p=0.03). No significant association was detected between 8-OHdG in oral cells and other variables such as passive smoke, oral infections, alcohol or vitamin intake andgrilled food consumption. This work suggests that tobacco smoke and environmental exposure to pollutants lead to a measurable increase of oxidative damage in oral cells and confirms that the immunoperoxidase method is an appropriate approach for epidemiological analyses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:40:24