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Titolo:
Comparative study of the acute nephrotoxicity from standard dose cisplatin+/- ifosfamide and high-dose chemotherapy with carboplatin and ifosfamide
Autore:
Hartmann, JT; Fels, LM; Franzke, A; Knop, S; Renn, M; Maess, B; Panagiotou, P; Lampe, H; Kanz, L; Stolte, H; Bokemeyer, C;
Indirizzi:
Univ Tubingen, UKT Med Ctr 2, Dept Hematol Oncol Immunol, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 mmunol, D-72076 Tubingen, Germany Univ Hannover, Sch Med, Div Nephrol, Hannover, Germany Univ Hannover Hannover Germany Sch Med, Div Nephrol, Hannover, Germany Univ Hannover, Sch Med, Div Hematol & Oncol, Hannover, Germany Univ Hannover Hannover Germany , Div Hematol & Oncol, Hannover, Germany Krankenhaus Siloah, Dept Hematol & Oncol, Hannover, Germany Krankenhaus Siloah Hannover Germany Hematol & Oncol, Hannover, Germany Klinikum 2, Dept Hematol & Oncol, Minden, Germany Klinikum 2 Minden Germany ikum 2, Dept Hematol & Oncol, Minden, Germany Soc Sci & Technol Transfer GWT EV, Berlin, Germany Soc Sci & Technol Transfer GWT EV Berlin Germany WT EV, Berlin, Germany
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5C, volume: 20, anno: 2000,
pagine: 3767 - 3773
SICI:
0250-7005(200009/10)20:5C<3767:CSOTAN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERM-CELL TUMORS; RENAL-FUNCTION; PHASE-II; ETOPOSIDE; TOXICITY; CANCER; MESNA; CHILDREN; SUPPORT; RESCUE;
Keywords:
nephrotoxicity; cisplatin; ifosfamide; carboplatin; glomerular filtration rate; urinary markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hartmann, JT Univ Tubingen, UKT Med Ctr 2, Dept Hematol Oncol Immunol, Otfried Muller Str 10, D-72076 Tubingen, Germany Univ Tubingen Otfried Muller Str 10 Tubingen Germany D-72076
Citazione:
J.T. Hartmann et al., "Comparative study of the acute nephrotoxicity from standard dose cisplatin+/- ifosfamide and high-dose chemotherapy with carboplatin and ifosfamide", ANTICANC R, 20(5C), 2000, pp. 3767-3773

Abstract

The nephrotoxic effects of different platinum compounds based combination chemotherapies were compared. Chemotherapy consisted of either cisplatin fractionated over 5 days (5 x 20 mg/m(2)) or given as a single-day infusion (1 x 50 mg/m(2)) plus ifosfamide (4 g/m(2)) or high-dose chemotherapy was applied including carboplatin (3 x 500 mg/m(2)) and ifosfamide (3 x 4 g/m(2))fractionated over three consecutive days. Conventional parameters such as serum creatinine and glomerular filtration rate (GFR), as well as urinary protein excretion of N-acetyl-beta -D-glucosaminidase (NAG)) and alpha (1)-micro-globulin were assessed in 52 patients. Fractionation over 5 days without adding other nephrotoxic agents, Le. ifosfamide, prevented decreases in GFR following cisplatin, whereas the combination of conventional dose cisplatin and Ifosfamide, given as a single-day infusion, and high-close carboplatin/ifosfamide yielded a pronounced fall of GFR All groups showed increases in the urinary excretion levels of serum derived proteins and NAG, but with significant differences; about 2 to 3-fold for 5-days cisplatin, 3 to 5-fold for single-day cisplatin/ifosfamide, and 20 to 35-fold for high-dose chemotherapy. Thus conventional approaches can reduce but not prevent the nephrotoxicity of cisplatin-based chemotherapy. In particular, high-dose chemotherapy regimens including carboplatin and ifosfamide are associated with comparable or even higher nephrotoxicity to single-day cisplatin/ Ifosfamide. In the light of the long-term consequences of persistent renal damage prevention of nephrotoxicity should be further improved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 09:47:42