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Titolo:
Oxaliplatin is active in vitro against human melanoma cell lines: comparison with cisplatin and carboplatin
Autore:
Mohammed, MQ; Retsas, S;
Indirizzi:
Charing Cross Hosp, Hammersmith Hosp NHS Trust, Directorate Canc Serv & Haematol,Dept Med Oncol, Melanoma Unit,Catherine Griffiths Canc Res Lab, London W6 8RF, England Charing Cross Hosp London England W6 8RF Res Lab, London W6 8RF, England
Titolo Testata:
ANTI-CANCER DRUGS
fascicolo: 10, volume: 11, anno: 2000,
pagine: 859 - 863
SICI:
0959-4973(200011)11:10<859:OIAIVA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; MALIGNANT-MELANOMA; PHASE-I; CANCER;
Keywords:
activity; carboplatin; cisplatin; in vitro; melanoma; oxaliplatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Retsas, S Charing Cross Hosp, Hammersmith Hosp NHS Trust, Directorate CancServ & Haematol,Dept Med Oncol, Melanoma Unit,Catherine Griffiths Canc ResLab, Fulham Palace Rd, London W6 8RF, England Charing Cross Hosp Fulham Palace Rd London England W6 8RF gland
Citazione:
M.Q. Mohammed e S. Retsas, "Oxaliplatin is active in vitro against human melanoma cell lines: comparison with cisplatin and carboplatin", ANTI-CANC D, 11(10), 2000, pp. 859-863

Abstract

We have previously confirmed the in vitro activity of cisplatin and carboplatin against human melanoma cell lines. Both drugs are important components in the chemotherapy used in our service for advanced metastatic melanoma. In this communication we report the in vitro activity of oxaliplatin against human melanoma cell lines in comparison with cisplatin and carboplatin. Oxaliplatin was found to be active against C32 and G361 cell lines with IC50 values of 49.48 and 9.07 muM (1 h exposure), 9.47 and 1.30 muM (4 h exposure), and 0.98 and 0.14 muM (24 h exposure), respectively. The cytotoxic activity of oxaliplatin in this in vitro system appears to be significantly superior to that of carboplatin. Its activity becomes comparatively closer to that of cisplatin as exposure time increases. Indeed at a 24 h exposure oxaliplatin appears to be significantly more active than cisplatin against the G361 cell line (p=0.0343). Oxaliplatin merits evaluation in the clinic both as a single agent and in combination with other drugs active against melanoma. [(C) 2000 Lippincott Williams & Wilkins.].

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:50:06