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Titolo:
Factors predicting prognosis of epilepsy after presentation with seizures
Autore:
MacDonald, BK; Johnson, AL; Goodridge, DM; Cockerell, OC; Sander, JWAS; Shorvon, SD;
Indirizzi:
Univ London, Natl Hosp Neurol & Neurosurg, Dept Clin Neurol, Inst Neurol, London WC1N 3BG, England Univ London London England WC1N 3BG nst Neurol, London WC1N 3BG, England Inst Publ Hlth, MRC, Biostat Unit, Cambridge, England Inst Publ Hlth Cambridge England MRC, Biostat Unit, Cambridge, England Warders Med Ctr, Tonbridge, Kent, England Warders Med Ctr Tonbridge Kent England Med Ctr, Tonbridge, Kent, England
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 6, volume: 48, anno: 2000,
pagine: 833 - 841
SICI:
0364-5134(200012)48:6<833:FPPOEA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATIONAL GENERAL-PRACTICE; 1ST UNPROVOKED SEIZURE; ANTIEPILEPTIC DRUG-THERAPY; FOLLOW-UP; ANTICONVULSANTS ALTER; CHILDHOOD EPILEPSY; NATURAL COURSE; REMISSION; CHILDREN; RECURRENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Shorvon, SD Univ London, Natl Hosp Neurol & Neurosurg, Dept Clin Neurol, Inst Neurol, Queen Sq, London WC1N 3BG, England Univ London Queen Sq LondonEngland WC1N 3BG C1N 3BG, England
Citazione:
B.K. MacDonald et al., "Factors predicting prognosis of epilepsy after presentation with seizures", ANN NEUROL, 48(6), 2000, pp. 833-841

Abstract

The objective of this study was to identify the factors, at the time of diagnosis, that determine the prognosis for remission of epilepsy. A prospective community-based cohort study of 792 patients recruited at the time of their first diagnosis of epileptic seizures was undertaken; in those classified 6 months after presentation, the median follow-up period was 7.2 years (quartiles at 6.2 and 8.2 years) after presentation. We analyzed data from 6 months after the first identified seizure, which prompted the dianosis ofepilepsy, to allow us to factor in those aspects contingent on a diagnostic assessment. Baseline clinical and demographic data were analyzed using the Cox proportional hazards regression model with remission of epilepsy for 1, 2, 3, and 5 years as outcome measures. The dominant clinical feature predicting remission was the number of seizures in the 6-month diagnostic assessment period Thus, the chance of entering 1 year of remission by 6 years for a patient who had 2 seizures during this initial 6 months was 95%; for 5years of remission, it was 47% as opposed to 75% for 1 year of remission and 24% for 5 years of remission if there had been 10 or more seizures during this period, The number of seizures in the early phase of epilepsy there,taken as the first 6 months after presentation) is the single most important predictive factor for both early and long-term remission of seizures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:34:51