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Titolo:
PET contributions to understanding normal and abnormal cardiac perfusion and metabolism
Autore:
Schelbert, HR;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA90095 USA Univ Calif Los Angeles, Sch Med, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
ANNALS OF BIOMEDICAL ENGINEERING
fascicolo: 8, volume: 28, anno: 2000,
pagine: 922 - 929
SICI:
0090-6964(200008)28:8<922:PCTUNA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; MYOCARDIAL BLOOD-FLOW; CORONARY-ARTERY DISEASE; HIBERNATING MYOCARDIUM; NONINVASIVE QUANTIFICATION; OXIDATIVE-METABOLISM; ISCHEMIC-HEART; C-11 ACETATE; N-13 AMMONIA; F-18 FLUORODEOXYGLUCOSE;
Keywords:
positron emission tomography; glucose; free fatty acid; oxidative metabolism; tracer kinetic modeling; myocardium; ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Schelbert, HR Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, 23-120 CHS, LosAngeles, CA 90095 USA Univ Calif Los Angeles 23-120 CHS Los Angeles CA USA 90095 A
Citazione:
H.R. Schelbert, "PET contributions to understanding normal and abnormal cardiac perfusion and metabolism", ANN BIOMED, 28(8), 2000, pp. 922-929

Abstract

Noninvasive positron emission tomography (PET)-based studies of myocardialblood flow and substrate metabolism characterized the human heart as an organ fully integrated with the general function of the human body. Cardiac energy demands are tightly coupled to peripheral needs in oxygen and, in turn, govern changes in myocardial blood flow and substrate supply. Substrate selection and utilization depend largely on substrate availability and, hence, on concentrations of fuel substrate in brood. Endocrine and neuronal factors together with regional transport processes modulate and fine tune regional rates of substrate utilization. Manipulation of substrate availability as for example through dietary or pharmacologic maneuvers offer a means to probe regional substrate interactions, to demonstrate shifts in substrateselection between free fatty acid and glucose and, hence, to confirm the operation of regulatory mechanisms established previously in animal experiments. In abnormal states, local factors modulate the generally integrated responses and synchronize regional substrate utilization and metabolism with regional needs. Diminished substrate delivery in chronic low flow conditions is matched by a down regulation in regional contractile function possiblyas an energy saving measure, together with a decline in oxidative metabolism as evidenced by reduced oxidation of C-11-palmitate and delayed turnoverof C-11-acetate. Activation of rate controlling enzymes together with enhanced transmembraneous transport systems represent flux generating steps forenhanced regional glucose consumption possibly as a means for reducing oxygen needs and at the same time, preserving cellular homeostasis. PET identifies such regional metabolic adjustments as regional increases in F-18-deoxyglucose uptake as a clinically useful hallmark of myocardial viability. Regional glucose utilization in this case no longer fully responds to generalcontrol mechanisms of substrate selection but is modified by local factorsor, ultimately may become part of a local microsystem as a means of protection against potentially deleterious consequences of disease. (C) 2000 Biomedical Engineering Society. [S0090-6964(00)01808-7].

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:56:30