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Titolo:
Temporal lobe dysfunction in childhood autism: A PET study
Autore:
Zilbovicius, M; Boddaert, N; Belin, P; Poline, JB; Remy, P; Mangin, JF; Thivard, L; Barthelemy, C; Samson, Y;
Indirizzi:
CEA, Serv Hosp Frederic Joliot, Direct Sci Vivant, Dept Rech Med, F-91406 Orsay, France CEA Orsay France F-91406 ci Vivant, Dept Rech Med, F-91406 Orsay, France INSERM, Tours, France INSERM Tours FranceINSERM, Tours, France Hop La Pitie Salpetriere, Serv Urgences Cerebrovasc, Paris, France Hop La Pitie Salpetriere Paris France gences Cerebrovasc, Paris, France
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 12, volume: 157, anno: 2000,
pagine: 1988 - 1993
SICI:
0002-953X(200012)157:12<1988:TLDICA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HERPES-SIMPLEX ENCEPHALITIS; CEREBRAL BLOOD-FLOW; SUMMARIZED EVALUATION; BRAIN; METABOLISM; GLUCOSE; CHILDREN; CORTEX; SCALE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Zilbovicius, M CEA, Serv Hosp Frederic Joliot, Direct Sci Vivant, Dept Rech Med, 4 Pl GenLeclerc, F-91406 Orsay, France CEA 4 Pl Gen Leclerc Orsay France F-91406 06 Orsay, France
Citazione:
M. Zilbovicius et al., "Temporal lobe dysfunction in childhood autism: A PET study", AM J PSYCHI, 157(12), 2000, pp. 1988-1993

Abstract

Objective: The nature of the underlying brain dysfunction of childhood autism, a life-long severe developmental disorder, is not well understood. Although researchers using functional brain imaging have attempted to contribute to this debate, previous studies have failed to report consistent localized neocortical brain dysfunction. The authors reasoned that early methods may have been insensitive to such dysfunction, which may now be detectable with improved technology. Method: To test this hypothesis, regional cerebral blood flow was measuredwith positron emission tomography (PET) in 21 children with primary autismand in 10 nonautistic children with idiopathic mental retardation. Autistic and comparison groups were similar in average age and developmental quotients. The authors first searched for focal brain dysfunction in the autistic group by using a voxel-based whole brain analysis and then assessed the sensitivity of the method to detect the abnormality in individual children. An extension study was then performed in an additional group of 12 autisticchildren. Results: The first autistic group had a highly significant hypoperfusion in both temporal lobes centered in associative auditory and adjacent multimodal cortex, which was detected in 76% of autistic children. Virtually identical results were found in the second autistic group in the extension study. Conclusions: PET and voxel-based image analysis revealed a localized dysfunction of the temporal lobes in school-aged children with idiopathic autism. Further studies will clarify the relationships between these temporal abnormalities and the perceptive, cognitive, and emotional developmental abnormalities characteristic of this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:21:07