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Titolo:
Concerted action of dopamine on renal and intestinal Na+-K+-ATPase in the rat remnant kidney
Autore:
Vieira-Coelho, MA; Serrao, P; Guimaraes, JT; Pestana, M; Soares-Da-Silva, P;
Indirizzi:
Fac Med Porto, Inst Pharmacol & Therapeut, P-4200 Oporto, Portugal Fac MedPorto Oporto Portugal P-4200 Therapeut, P-4200 Oporto, Portugal
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 6, volume: 279, anno: 2000,
pagine: F1033 - F1044
SICI:
0363-6127(200012)279:6<F1033:CAODOR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY-EXCRETION; GASTROINTESTINAL-TRACT; SODIUM-EXCRETION; SYSTEM ACTIVITY; SALT INTAKE; INHIBITION; METABOLITES; TRANSPORTER; ACTIVATION; MECHANISM;
Keywords:
intestine; sodium-potassium-adenosine-5 '-triphosphatase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Soares-Da-Silva, P Fac Med Porto, Inst Pharmacol & Therapeut, P-4200 Oporto, Portugal Fac Med Porto Oporto Portugal P-4200 Oporto, Portugal
Citazione:
M.A. Vieira-Coelho et al., "Concerted action of dopamine on renal and intestinal Na+-K+-ATPase in the rat remnant kidney", AM J P-REN, 279(6), 2000, pp. F1033-F1044

Abstract

The present study evaluated renal and intestinal adaptations in sodium handling in uninephrectomized (Unx) rats and the role of dopamine. Two weeks after uninephrectomy, the remnant kidney in Unx rats weighed 33 +/- 2% more than the corresponding kidney in sham-operated (Sham) animals. This was accompanied by increases in urinary levels of dopamine and major metabolites [3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid] and increasesin maximal velocity values (169 vs. 115 nmol.mg protein(-1).15 min(-1)) for renal aromatic L-amino acid decarboxylase, the enzyme responsible for thesynthesis of renal dopamine. High salt (HS) intake increased (P < 0.05) the urinary excretion of dopamine and DOPAC in Unx and Sham rats. However, the urinary levels of L-3,4-dihydroxyphenylalanine, dopamine, and DOPAC in Sham rats during HS intake were lower than in Unx rats. Blockade of dopamine D-1 receptors (Sch-23390, 2 x 30 <mu>g/kg) reduced the urinary excretion ofsodium in Unx (31% decrease) more pronouncedly than in Sham (19% decrease)rats. However, inhibition of renal Na+-K+-ATPase activity by dopamine was of similar magnitude in Unx and Sham rats. In parallel, it was observed that uninephrectomy resulted in a significant reduction in jejunal sodium absorption and Na+-K+-ATPase activity in jejunal epithelial cells. In jejunal epithelial cells from Sham rats, dopamine (1 muM) failed to inhibit Na+-K+-ATPase activity, whereas in Unx rats it produced a significant reduction. Itis concluded that uninephrectomy results in increased renal dopaminergic activity and dopamine-sensitive enhanced natriuresis. Furthermore, it is suggested that decreased jejunal absorption of sodium may take place in response to partial renal ablation, as an example of renal-intestinal cross talk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:48:35