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Titolo:
CD5+follicle center lymphoma - Immunophenotyping detects a unique subset of "floral" follicular lymphoma
Autore:
Tiesinga, JJ; Wu, CD; Inghirami, G;
Indirizzi:
NYU, Med Ctr, Sch Med, Dept Pathol,Hematopathol Div, New York, NY 10016 USA NYU New York NY USA 10016 Pathol,Hematopathol Div, New York, NY 10016 USA
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 6, volume: 114, anno: 2000,
pagine: 912 - 921
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; POLYMERASE-CHAIN-REACTION; FLOW CYTOMETRIC ANALYSIS; B-CELL LINEAGE; LY-1 B; BONE-MARROW; MALIGNANT-LYMPHOMAS; SURFACE EXPRESSION; ANTIGEN EXPRESSION; DENDRITIC CELLS;
Keywords:
follicle center lymphoma; floral variant; CD5; flow cytometry; immunohistochemistry; non-Hodgkin lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Tiesinga, JJ NYU, Med Ctr, Sch Med, Dept Pathol,Hematopathol Div, 560 1st Ave, New York, NY 10016 USA NYU 560 1st Ave New York NY USA 10016 New York, NY 10016 USA
Citazione:
J.J. Tiesinga et al., "CD5+follicle center lymphoma - Immunophenotyping detects a unique subset of "floral" follicular lymphoma", AM J CLIN P, 114(6), 2000, pp. 912-921

Abstract

The "floral" variant of follicle center lymphoma (FCL) may be confused with progressive transformation of germinal centers or lymphocyte predominanceHodgkin lymphoma. Immunohistochemistry and gene rearrangement studies are usually sufficient to differentiate among these entities. We present 11 cases of floral FCL that were evaluated at our institution by flow cytometry, immunohistochemistry, or both and by polymerase chain reaction-based molecular analysis. In 4 cases, the neoplastic B cells coexpressed CD5 antigens; 3 of these 4 cases also were CD10+, and all demonstrated rearrangement within the bcl-2 locus. These findings demonstrate that a subset of floral FCL is CD5+. Recognition of this immunophenotype is important to avoid misdiagnosis of nodular variants of small lymphocytic lymphoma and mantle cell lymphoma. Studies suggest that expression of CD5 by neoplastic germinal center cells might result from alterations of the follicular microenvironment and/or inappropriate B-cell responses to cytokine networks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:15:04