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Titolo:
Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults
Autore:
Binkley, NC; Krueger, DC; Engelke, JA; Foley, AL; Suttie, JW;
Indirizzi:
Univ Wisconsin, Dept Med, Inst Aging, Madison, WI USA Univ Wisconsin Madison WI USA sin, Dept Med, Inst Aging, Madison, WI USA Univ Wisconsin, Dept Biochem, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 , Dept Biochem, Madison, WI 53705 USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 6, volume: 72, anno: 2000,
pagine: 1523 - 1528
SICI:
0002-9165(200012)72:6<1523:VKSRSC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CALCIUM EXCRETION; BONE-MINERAL DENSITY; UNDERCARBOXYLATED OSTEOCALCIN; ORAL ANTICOAGULANTS; HIP FRACTURE; DIETARY PHYLLOQUINONE; CARBOXYGLUTAMIC ACID; WOMEN; PLASMA; RISK;
Keywords:
vitamin K; phylloquinone; osteocalcin; undercarboxylated osteocalcin; ucOC; bone turnover; osteoporosis; elderly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Binkley, NC 2245 MSC,1300 Univ Ave, Madison, WI 53706 USA 2245 MSC,1300 Univ Ave Madison WI USA 53706 son, WI 53706 USA
Citazione:
N.C. Binkley et al., "Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults", AM J CLIN N, 72(6), 2000, pp. 1523-1528

Abstract

Background: Subclinical vitamin K insufficiency, manifested by under-gamma-carboxylation of the bone matrix protein osteocalcin, may be common. Objective: Our objective was to delineate the prevalence of submaximal gamma -carboxylation as assessed by response to phylloquinone supplementation and to evaluate the effect of this intervention on skeletal turnover in healthy North American adults. Design: Healthy subjects (n = 219), approximately equally distributed by sex and age (18-30 y and greater than or equal to 65 y), received daily phylloquinone (1000 mug) or placebo for 2 wk. Serum undercarboxylated osteocalcin (ucOC) and total osteocalcin, N-telopeptides of type I collagen (NTx), bone-specific alkaline phosphatase (BSAP), and phylloquinone concentrations were measured at baseline and after weeks 1 and 2. Results: At baseline, the mean serum phylloquinone concentration was lowerin the young than in the old group; there was no effect of sex. Concomitantly, baseline %ucOC was highest in the young and lowest in the old men (P <0.0001) but did not differ significantly by age in women. After supplementation, serum phylloquinone concentration increased <approximate to>10-fold (P < 0.0001) at week 1 (from 0.93 +/- 0.08 to 8.86 +/- 0.70 nmol/L, <(x)over bar> +/- SEM); this was sustained through week 2. Among all supplemented groups, mean %ucOC decreased from 7.6% to 3.4% without significant differences by age or sex; 102 of 112 subjects had a > 1% decrease. Phylloquinone supplementation reduced serum osteocalcin but did not alter NTx or BSAP concentration. Conclusions: Usual dietary practices in this population did not provide adequate vitamin K for maximal osteocalcin carboxylation. Phylloquinone supplementation reduced serum osteocalcin concentration but did not alter other markers of serum bone turnover.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:29:17