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Titolo:
EFFECT OF HELICOBACTER-PYLORI ERADICATION ON GASTRITIS IN RELATION TOCAGA - A PROSPECTIVE 1-YEAR FOLLOW-UP-STUDY
Autore:
VANDERHULST RWM; VANDERENDE A; DEKKER FW; TENKATE FJW; WEEL JFL; KELLER JJ; KRUIZINGA SP; DANKERT J; TYTGAT GNJ;
Indirizzi:
UNIV AMSTERDAM,ACAD MED CTR,DEPT GASTROENTEROL,MEIBERGDREEF 9 NL-1105AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT MED MICROBIOL NL-1105 AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT CLIN EPIDEMIOL & BIOSTAT NL-1105 AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT HISTOPATHOL NL-1105 AZ AMSTERDAM NETHERLANDS
Titolo Testata:
Gastroenterology
fascicolo: 1, volume: 113, anno: 1997,
pagine: 25 - 30
SICI:
0016-5085(1997)113:1<25:EOHEOG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIN ACTIVITY; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R.W.M. Vanderhulst et al., "EFFECT OF HELICOBACTER-PYLORI ERADICATION ON GASTRITIS IN RELATION TOCAGA - A PROSPECTIVE 1-YEAR FOLLOW-UP-STUDY", Gastroenterology, 113(1), 1997, pp. 25-30

Abstract

Background & Aims: Whether Helicobacter pylori eradication resolves intestinal metaplasia and atrophy and whether infection with cagA(+) H.pylori is related to a specific clinical outcome are not known. The aim of this study was to investigate the role of H. pylori eradication on the course of intestinal metaplasia (IM) and atrophy in relation tocagA. Methods: In a large prospective study, the cag4 status of H. pylori isolated from consecutive dyspeptic patients was related to clinical outcome before and 1 year after successful eradication of H. pylori. At pretreatment and 4-6 weeks and on average 1 year after eradication therapy, the degree of gastritis and the status of H. pylori were assessed by culture and histopathology. Results: Specimens of cagA(+) H. pylori were recovered from 122 of 155 (79%) patients infected with H. pylori. Pretreatment degrees of gastritis activity, superficial epithelial damage, IM, and atrophy were significantly greater in patients infected with cagA(+) H. pylori (P < 0.001). After successful eradication of H. pylori, a significant improvement of activity of gastritis and superficial epithelial damage occurred (P < 0.001), but the degree of IM and atrophy did not change, irrespective of the cagA status. Conclusions: The usefulness of H. pylori eradication to revert precancerous lesions such as IM and atrophy after 1-year follow-up is questionable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:53:53