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Titolo:
Elevation of neuron-specific enolase in serum and cerebrospinal fluid of early stage Creutzfeldt-Jakob disease
Autore:
Kohira, I; Tsuji, T; Ishizu, H; Takao, Y; Wake, A; Abe, K; Kuroda, S;
Indirizzi:
Okayama Univ, Sch Med, Dept Neurol, Okayama, Japan Okayama Univ Okayama Japan a Univ, Sch Med, Dept Neurol, Okayama, Japan Okayama Univ, Sch Med, Dept Neuropsychiat, Okayama, Japan Okayama Univ Okayama Japan Sch Med, Dept Neuropsychiat, Okayama, Japan Kurashiki Heisei Hosp, Kurashiki, Okayama, Japan Kurashiki Heisei Hosp Kurashiki Okayama Japan Kurashiki, Okayama, Japan
Titolo Testata:
ACTA NEUROLOGICA SCANDINAVICA
fascicolo: 6, volume: 102, anno: 2000,
pagine: 385 - 387
SICI:
0001-6314(200012)102:6<385:EONEIS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Keywords:
Creutzfeldt-Jakob disease (CJD); neuron-specific enolase (NSE); serum; cerebrospinal fluid (CSF); dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Kohira, I Kochi Municipal Cent Hosp, Dept Neurol, 2-7-33 Sakurai Cho, Kochi 7800821,Japan Kochi Municipal Cent Hosp 2-7-33 Sakurai Cho Kochi Japan 7800821
Citazione:
I. Kohira et al., "Elevation of neuron-specific enolase in serum and cerebrospinal fluid of early stage Creutzfeldt-Jakob disease", ACT NEUR SC, 102(6), 2000, pp. 385-387

Abstract

Objective - To investigate the levels of neuron-specific enolase (NSE) in serum and cerebrospinal fluid (CSF) of patients with early stage Creutzfeldt-Jakob disease (CJD). Methods - The levels of NSE in serum and CSF were examined in 6 cases with CJD patients. The levels of NSE in CSF were measuredin 8 age matched control patients with other neurological diseases and thelevels of serum NSE were also measured in another 8 age matched control patients with other neurological diseases. The groups of 8 age matched control patients consisted of I same patient and 7 different patients in the 2 control groups both for serum and CSF. Results - The level of serum NSE in CJD (17.3 +/- 7.0 ng/ml, mean +/- SD) was significantly higher than that of controls (6.5 +/- 1.6) (P <0.02) as was the case in CSF (79.3 +/- 53.3 ng/ml) vs (9.6 +/- 2.9) (P <0.03). Conclusion Although mean NSE levels of CJD were higher in CSF than in the serum, there still is a case with higher serumNSE level than CSF. These results suggest that the mechanism of elevation of serum NSE may not be a simple leakage from CSF, and that the measurementof serum NSE level may be useful for diagnosis of early stage CJD.

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Documento generato il 23/01/20 alle ore 03:29:37