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Titolo:
The hypothalamic-pituitary-adrenocortical and gonadal axis function in rheumatoid arthritis
Autore:
Cutolo, M; Giusti, M; Foppiani, L; Seriolo, B; Briata, M; Bisso, A; Faelli, F; Felli, L; Prete, C; Pizzorni, C; Sulli, A;
Indirizzi:
Univ Genoa, Dept Internal Med, Div Rheumatol, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 Med, Div Rheumatol, I-16132 Genoa, Italy Univ Genoa, Dept Orthoped, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 enoa, Dept Orthoped, I-16132 Genoa, Italy Univ Genoa, DISEM, Div Endocrinol, I-16132 Genoa, Italy Univ Genoa GenoaItaly I-16132 SEM, Div Endocrinol, I-16132 Genoa, Italy
Titolo Testata:
ZEITSCHRIFT FUR RHEUMATOLOGIE
, volume: 59, anno: 2000, supplemento:, 2
pagine: 65 - 69
SICI:
0340-1855(2000)59:<65:THAGAF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE ACTH; ADRENAL AXIS; SYNOVIAL MACROPHAGES; AROMATASE-ACTIVITY; SEX-HORMONES; LIFE EVENTS; INTERLEUKIN-6; ANDROGEN; GLUCOCORTICOIDS; AUTOIMMUNITY;
Keywords:
hypothalamic-pituitary-adrenocortical axis; androgens; estrogens; rheumatoid arthritis; inflammation; sex hormones; cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Cutolo, M Univ Genoa, Dept Internal Med, Div Rheumatol, Viale Benedetto VX,6, I-16132 Genoa, Italy Univ Genoa Viale Benedetto VX,6 Genoa Italy I-16132 enoa, Italy
Citazione:
M. Cutolo et al., "The hypothalamic-pituitary-adrenocortical and gonadal axis function in rheumatoid arthritis", Z RHEUMATOL, 59, 2000, pp. 65-69

Abstract

The altered cortisol and adrenal androgen (i.e., dehydroepiandrosterone sulfate = DHEAS) secretion, observed during testing in rheumatoid arthritis (RA) patients not treated with corticosteroids, should be clearly regarded as a "relative adrenal insufficiency" in the setting of a sustained inflammatory process, as shown by high serum IL-6 levels. Androgens seem implicatedin the pathophysiology of autoimmune disorders, including RA, as natural immunosuppressors. Low plasma and synovial fluid testosterone concentrationsare observed in male RA patients; low plasma DHEAS levels are mainly observed in female RA patients. The menopausal peak of RA suggests that estrogens and/or progesterone deficiency also play a role in the disease, and many data indicate that estrogens suppress cellular immunity, but stimulate humoral immunity (i.e., deficiency promotes cellular Th 1-type immunity). Gene polymorphisms for enzymes involved in the steroidogenesis seem to further complicate the role of sex hormones in the susceptibility to autoimmunity. Acquired changes of sex steroid metabolism seem to also play a role in the peripheral sex hormone levels. In conclusion, a complex interaction between the hypothalamus-pituitary-adrenocortical and gonadal axis functions is evident in RA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:01:21