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Titolo:
New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders
Autore:
Reul, JMHM; Bilang-Bleuel, A; Droste, S; Linthorst, ACE; Holsboer, F; Gesing, A;
Indirizzi:
Max Planck Inst Psychiat, Sect Neuropsychopharmacol, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
ZEITSCHRIFT FUR RHEUMATOLOGIE
, volume: 59, anno: 2000, supplemento:, 2
pagine: 22 - 25
SICI:
0340-1855(2000)59:<22:NMOHAR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOID RECEPTOR FUNCTION; TRANSGENIC MICE; RAT; BRAIN; CHALLENGE; NEURONS; SYSTEMS; ANXIETY;
Keywords:
mineralocorticoid receptor; glucocorticoid receptor; corticotropin-releasing hormone; hypothalamic-pituitary-adrenocortical axis; brain; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Reul, JMHM Max Planck Inst Psychiat, Sect Neuropsychopharmacol, Kraepelinstr 2, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 2 Munich Germany D-80804
Citazione:
J.M.H.M. Reul et al., "New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders", Z RHEUMATOL, 59, 2000, pp. 22-25

Abstract

Two types of corticosteroid receptors have been identified in the brain and pituitary that play an important role in the regulation of the hypothalamic-pituitary-adrenocortical (HPA) axis. These glucocorticoid hormone binding receptors are the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). Evidently, a tight control of the concentration and functionof these receptors is of prime importance for maintaining and regaining homeostasis after stressful challenges. Here, we describe a navel mechanism revealing a rapid upsurge in MR density in the hippocampus (a limbic structure highly involved in HPA axis regulation) after an acute psychologically stressful challenge. This rise in MR is accompanied by a stronger MR-mediated inhibitory control of the HPA axis. Thus, an acute stressful experience results in a reorganization of the HPA axis involving a principal role of the hippocampal MR. This novel mechanism may be of significance for increasing our understanding of the etiology of stress-related disorders.

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Documento generato il 25/01/20 alle ore 19:42:35