Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tumorigenesis of Epstein-Barr virus-positive epithelial cell lines derivedfrom gastric tissues in the SCID mouse
Autore:
Murakami, M; Hoshikawa, Y; Satoh, Y; Ito, H; Tajima, M; Okinaga, K; Miyazawa, Y; Kurata, T; Sairenji, T;
Indirizzi:
Tottori Univ, Fac Med, Sch Life Sci, Dept Biosignaling, Yonago, Tottori 683503, Japan Tottori Univ Yonago Tottori Japan 683503 g, Yonago, Tottori 683503, Japan Tottori Univ, Fac Med, Dept Pathol, Yonago, Tottori 683503, Japan Tottori Univ Yonago Tottori Japan 683503 l, Yonago, Tottori 683503, Japan Teikyo Univ, Sch Med, Dept Clin Pathol, Tokyo 1730003, Japan Teikyo Univ Tokyo Japan 1730003 , Dept Clin Pathol, Tokyo 1730003, Japan Teikyo Univ, Sch Med, Dept Surg 2, Tokyo 1730003, Japan Teikyo Univ Tokyo Japan 1730003 h Med, Dept Surg 2, Tokyo 1730003, Japan Natl Inst Infect Dis, Dept Pathol, Tokyo 1620052, Japan Natl Inst Infect Dis Tokyo Japan 1620052 pt Pathol, Tokyo 1620052, Japan
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 277, anno: 2000,
pagine: 20 - 26
SICI:
0042-6822(20001110)277:1<20:TOEVEC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOID STROMA; CARCINOMA; INFECTION; ADENOCARCINOMA; ESTABLISHMENT; STOMACH; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Sairenji, T Tottori Univ, Fac Med, Sch Life Sci, Dept Biosignaling, Nishimachi 86, Yonago, Tottori 683503, Japan Tottori Univ Nishimachi 86 Yonago Tottori Japan 683503 , Japan
Citazione:
M. Murakami et al., "Tumorigenesis of Epstein-Barr virus-positive epithelial cell lines derivedfrom gastric tissues in the SCID mouse", VIROLOGY, 277(1), 2000, pp. 20-26

Abstract

To study the tumorigenesis of Epstein-Barr virus (EBV)-positive epithelialcell lines GT38 and GT39 derived from human gastric tissues, we inoculatedthese cells under the skin of severe combined immunodeficient (SCID) mice. The development of tumors was observed in each of the mice about 2 months after the inoculation. The tumors were diagnosed with undifferentiated carcinoma by hematoxylin/eosin staining. EBV-encoded small RNA1 was detected inthe paraffin-embedded tumor sections. The tumor cells had human chromosome. The circular, but not linear, EBV DNA was detected in the tumors. The molecular sizes of EBV DNA termini were the same as that of the inoculated GT38 or GT39 cells. The expressions of EBV nuclear antigen 2 and latent membrane protein 1 reduced in the tumors. Transcripts of BamHI C and W promoters in latency III were detected in the tumors and the cultured cells in vitro. The tumor cells were passaged from one SCID mouse to other SCID mice and to cultures in vitro. This is the first evidence that the EBV-positive epithelial cell lines produced tumors in the SCID mouse, (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:09:04