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Titolo:
Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography
Autore:
Voytko, ML; Mach, RH; Gage, HD; Ehrenkaufer, RLE; Efange, SMN; Tobin, JR;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Comparat Med Sect, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Anat, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Radiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Pharmacol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Anesthesiol, Winston Salem, NC27157 USA Wake Forest Univ Winston Salem NC USA 27157 l, Winston Salem, NC27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Pediat, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Univ Minnesota, Dept Radiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Radiol, Minneapolis, MN 55455 USA Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 d Chem, Minneapolis, MN 55455 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 39, anno: 2001,
pagine: 95 - 100
SICI:
0887-4476(200101)39:1<95:CAOARM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR ACETYLCHOLINE TRANSPORTER; SYNAPTIC VESICLES; VESAMICOL RECEPTOR; AUTORADIOGRAPHIC DISTRIBUTION; RAT-BRAIN; BINDING; SYSTEM; PET; ACETYLTRANSFERASE; NEOCORTEX;
Keywords:
aging; rhesus monkey; functional imaging; individual differences; vesicular acetylcholine transporter; cholinergic terminals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Voytko, ML Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Comparat Med Sect, MedCtr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 57 USA
Citazione:
M.L. Voytko et al., "Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography", SYNAPSE, 39(1), 2001, pp. 95-100

Abstract

In the present study, the radiotracer [F-18](+)-4-fluorobenzyltrozamicol ((+)-[F-18]FBT) and positron emission tomography (PET) were used to examine the vesicular acetylcholine transporter and determine if presynaptic cholinergic activity was altered with age in 23 rhesus monkeys that varied in agefrom 10 to 37 years. Binding of (+)-[F-18]FBT in the basal ganglia was reduced significantly with increasing age of the monkeys. However, there were individual differences noted in that some middle-aged and aged monkeys demonstrated levels of (+)-[F-18]FBT binding that were comparable to the binding measured in adult monkeys. These data indicate that presynaptic cholinergic function may decrease with age, but that there may be a differential susceptibility of the cholinergic system to the aging process in different individuals. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:42:35