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Titolo:
Changes in the pattern of brain-derived neurotrophic factor immunoreactivity in the rat brain after acute and subchronic haloperidol treatment
Autore:
Dawson, NM; Hamid, EH; Egan, MF; Meredith, GE;
Indirizzi:
Univ Missouri, Sch Med, Dept Basic Med Sci, Kansas City, MO 64108 USA UnivMissouri Kansas City MO USA 64108 Med Sci, Kansas City, MO 64108 USA Natl Univ Ireland Univ Coll Dublin, Dept Human Anat & Physiol, Dublin 4, Ireland Natl Univ Ireland Univ Coll Dublin Dublin Ireland 4 l, Dublin 4, Ireland NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Brain Disorders Branch, Bethesda, MD 20892 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 39, anno: 2001,
pagine: 70 - 81
SICI:
0887-4476(200101)39:1<70:CITPOB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC NEUROLEPTIC TREATMENT; VACUOUS CHEWING MOVEMENTS; MIDBRAIN DOPAMINE NEURONS; MEDIAL PREFRONTAL CORTEX; MESSENGER-RNA LEVELS; SUBSTANTIA-NIGRA; NUCLEUS-ACCUMBENS; ANTEROGRADE TRANSPORT; MORPHOLOGICAL-CHANGES; EXTRACELLULAR LEVELS;
Keywords:
neurotrophin; ventral tegmental area; nucleus accumbens; extended amygdala;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Meredith, GE Univ Missouri, Sch Med, Dept Basic Med Sci, 2411 Holmes St,M3-CO3, Kansas City, MO 64108 USA Univ Missouri 2411 Holmes St,M3-CO3 Kansas City MO USA 64108
Citazione:
N.M. Dawson et al., "Changes in the pattern of brain-derived neurotrophic factor immunoreactivity in the rat brain after acute and subchronic haloperidol treatment", SYNAPSE, 39(1), 2001, pp. 70-81

Abstract

Our earlier work has shown that repeated administration of classical neuroleptic drugs gives rise to structural alterations in target regions of the mesolimbic pathway, most notably, nucleus accumbens. Such changes could be responsible for the efficacious or motor side effects associated with thesedrugs. Growth factors such as brain-derived neurotrophic factor (BDNF) provide trophic support for dopaminergic neurons during development and mediate synaptic and morphological plasticity in numerous regions of the adult CNS. The present study examines whether BDNF is altered in the mesolimbic pathway by classical neuroleptic treatment. Animals were administered haloperidol, 0.5 mg/kg, or vehicle, i.p., for either 3 or 21 days, followed by transcardiac perfusion with fixative. Three days of haloperidol administration dramatically decreased BDNF immunostaining in the neurons and fibers of theprefrontal cortex, hippocampus (dentate gyrus, CA2, and CA3), extended amygdala, and ventral tegmental area. BDNF-immunoreactive fibers virtually disappeared from the neostriatum and nucleus accumbens. Subchronic (21 days) treatment led to a rebound in BDNF immunoreactivity in most cell bodies but not in fibers. These results show that blockade of dopaminergic receptors with haloperidol rapidly downregulates BDNF in reward and emotional centers of the brain. Such rapid inactivation and subsequent reappearance of BDNF immunoreactivity could affect synaptic strength and plasticity and thereforebe important preliminary steps in the cascade of neuronal events that leadto the efficacious or detrimental side effects of classical neuroleptic drugs. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 28/01/20 alle ore 15:52:57