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Titolo:
Decreased choline acetyltransferase immunoreactivity in discrete striatal subregions following chronic haloperidol in rats
Autore:
Grimm, JW; Chapman, MA; Zahm, DS; See, RE;
Indirizzi:
Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA St Louis Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63104 USA St Louis Univ St Louis MO USA 63104 t & Neurobiol, St Louis, MO 63104 USA Pacific Commun, Costa Mesa, CA USA Pacific Commun Costa Mesa CA USAPacific Commun, Costa Mesa, CA USA NIDA, Intramural Res Program, Baltimore, MD USA NIDA Baltimore MD USANIDA, Intramural Res Program, Baltimore, MD USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 39, anno: 2001,
pagine: 51 - 57
SICI:
0887-4476(200101)39:1<51:DCAIID>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; TARDIVE-DYSKINESIA; IMMUNOCYTOCHEMICAL LOCALIZATION; EXTRACELLULAR GLUTAMATE; ORAL BEHAVIOR; DOPAMINE; NEURONS; MOVEMENTS; PATHOPHYSIOLOGY; SCHIZOPHRENIA;
Keywords:
neuroleptic; haloperidol; striatum; nucleus accumbens; choline acetyltransferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: See, RE Med Univ S Carolina, Dept Physiol & Neurosci, 167 Ashley Ave, Charleston, SC 29425 USA Med Univ S Carolina 167 Ashley Ave Charleston SC USA 29425 425 USA
Citazione:
J.W. Grimm et al., "Decreased choline acetyltransferase immunoreactivity in discrete striatal subregions following chronic haloperidol in rats", SYNAPSE, 39(1), 2001, pp. 51-57

Abstract

Neuronal loss within the basal ganglia has been hypothesized to play a role in movement disorders (e.g., tardive dyskinesia) that often occur following chronic neuroleptic treatment. Previous studies in animal models have provided some support to this possibility, but have not assessed regionally specific changes after chronic neuroleptic administration. The present studyexamined whether counts of neurons containing acetylcholine, described as large aspiny type II neurons, were altered in subregions of the corpus striatum and nucleus accumbens following chronic haloperidol administration in rats. Rats were administered haloperidol decanoate (21 mg/kg, i.m.) or vehicle every third week for 24 weeks. Following 4 weeks of withdrawal from thedrug, predefined regions were examined for choline acetyltransferase (ChAT) immunoreactive (ir) cells. Compared to the vehicle group, the haloperidolgroup showed significant reductions in ChAT-ir cell counts in the ventrolateral striatum, nucleus accumbens core, and nucleus accumbens lateral shell. No significant differences were found in the other regions examined: dorsolateral striatum, dorsomedial striatum, ventromedial striatum, nucleus accumbens medial shell, and horizontal limb of the diagonal band. These findings indicate that there may be regionally specific alterations in ChAT-ir cells following chronic haloperidol treatment, supporting previous hypothesesof striatal cholinergic cell loss resulting from chronic neuroleptic treatment. More importantly, the regions affected (ventrolateral striatum and nucleus accumbens) are critical in the regulation of oral movement, thus suggesting that alterations in cholinergic cell activity, and perhaps actual loss of cholinergic cells in these regions, may be important in the manifestation of late-onset oral dyskinesia. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 22/01/20 alle ore 21:48:09