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Titolo:
Effect of chronic olanzapine treatment on striatal synaptic organization
Autore:
Roberts, RC;
Indirizzi:
Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Catonsville, MD 21228 USA Univ Maryland Catonsville MD USA 21228 sychiat, Catonsville, MD 21228 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 39, anno: 2001,
pagine: 8 - 15
SICI:
0887-4476(200101)39:1<8:EOCOTO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ORAL DYSKINESIAS; MEDIAL PREFRONTAL CORTEX; TARDIVE-DYSKINESIA; RAT NEOSTRIATUM; HALOPERIDOL TREATMENT; ANTIPSYCHOTIC-DRUGS; CHOLINERGIC NEURONS; DOPAMINERGIC AXONS; CHEWING MOVEMENTS; DENDRITIC SPINES;
Keywords:
caudate; antipsychotics; haloperidol; synapses; tardive dyskinesia; vacuous chewing movements;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, RC Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, POB 21247, Catonsville, MD 21228 USA Univ Maryland POB 21247 Catonsville MD USA 21228 MD 21228 USA
Citazione:
R.C. Roberts, "Effect of chronic olanzapine treatment on striatal synaptic organization", SYNAPSE, 39(1), 2001, pp. 8-15

Abstract

Our previous work has shown that chronic haloperidol treatment decreases striatal symmetric synapses preferentially in rats which develop oral dyskinesias (vacuous chewing movements (VCMs)). The present experiment tests the hypothesis that olanzapine, which does not cause dyskinesia in humans or rats, would not cause the ultrastructural changes produced by haloperidol. After 6 months of treatment, VCM scores for the olanzapine group (5.1 +/- 4.5) were similar to those of controls (5.2 +/- 3.9), whereas rats in the haloperidol group were either nondyskinetic (4.3 +/- 2.2) or dyskinetic (16.9 +/- 6.7). The volume of the striatum (mm(3)), did not differ among the groups: control, 37.5 +/- 4.7; olanzapine, 36.4 +/- 4.3; haloperidol, nondyskinetic, 40.5 +/- 6.3; haloperidol, dyskinetic, 36.6 +/- 5.9. Synaptic density (per 1 mum(3)), obtained from the central region of the striatum, did not differ between the olanzapine (0.699 +/- 0.146) and control groups (0.652 +/- 0.108). The number of asymmetric synapses in the olanzapine group (0.624 /- 0.136) was also similar to that of controls (0.550 +/- 0.090). The number of symmetric synapses in the olanzapine group (0.074 +/- 0.032) was not significantly different from that of controls (0.096 +/- 0.043). Thus, olanzapine, in contrast to haloperidol, did not produce dyskinesias or synapse loss. These results strengthen the correlation between the expression of VCMs and striatal synaptic changes and indicate that olanzapine has fewer behavioral and anatomical side effects than does haloperidol. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:38:05