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Titolo:
Neurotoxic regimen of methamphetamine produces evidence of behavioral sensitization in the rat
Autore:
Wallace, TL; Gudelsky, GA; Vorhees, CV;
Indirizzi:
Childrens Hosp Res Fdn, Div Dev Biol, Cincinnati, OH 45229 USA Childrens Hosp Res Fdn Cincinnati OH USA 45229 , Cincinnati, OH 45229 USA Univ Cincinnati, Grad Program Neurosci, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA d Program Neurosci, Cincinnati, OH USA Univ Cincinnati, Coll Pharm, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA innati, Coll Pharm, Cincinnati, OH USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 39, anno: 2001,
pagine: 1 - 7
SICI:
0887-4476(200101)39:1<1:NROMPE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; DOPAMINE RELEASE; INVIVO MICRODIALYSIS; REPEATED AMPHETAMINE; LOCOMOTOR-ACTIVITY; STRIATAL DOPAMINE; NUCLEUS; BRAIN; CAUDATE; TERM;
Keywords:
dopamine; serotonin; dopamine receptors; behavior; stereotypy; apomorphine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Vorhees, CV Childrens Hosp Res Fdn, Div Dev Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp Res Fdn 3333 Burnet Ave Cincinnati OH USA 45229
Citazione:
T.L. Wallace et al., "Neurotoxic regimen of methamphetamine produces evidence of behavioral sensitization in the rat", SYNAPSE, 39(1), 2001, pp. 1-7

Abstract

A neurotoxic regimen of methamphetamine (MA) produces long-term depletionsin neostriatal dopamine and serotonin concentrations. In addition to evidence of dopaminergic and serotonergic neurotoxicity, there is evidence of MA-induced behavioral changes. In this regard, stereotypic behavior elicited by MA is greater in rats treated previously with a neurotoxic regimen of MAthan in control animals. The present study was designed to determine whether the enhanced stereotypy observed in MA-treated rats is due to the MA-induced loss of dopamine (neurotoxicity) or to the repeated exposure to MA (sensitization). Rats were treated with MA (10 mg/kg every 2 h for four injections) or vehicle at either a normal(24 degreesC) room temperature or a cold(4 degreesC) room temperature, which has been shown to attenuate the MA-induced loss of dopamine. Stereotypy was assessed 7 days after treatment. Rats that had received a neurotoxic regimen of MA at 24 degreesC exhibited 49%and 45% reductions in neostriatal dopamine and serotonin concentrations, respectively, whereas rats treated with MA at 4 degreesC had no significant neurochemical depletions. Stereotypy elicited by MA (5.0 mg/kg) was significantly greater in rats treated with a neurotoxic regimen of MA regardless of the initial treatment temperature. In addition, an injection of apomorphine (0.5 mg/kg) elicited an enhanced stereotypic response in MA-treated rats. These data suggest that the augmented stereotypic behavior observed in rats treated with a neurotoxic regimen of MA is not due to the loss of dopamine, but rather the manifestation of behavioral sensitization, possibly due to an increase in dopamine receptor sensitivity. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 27/01/20 alle ore 07:21:53