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Titolo:
Fungal atopy in adult cystic fibrosis
Autore:
Henry, M; Bennett, DM; Kiely, J; Kelleher, N; Bredin, CP;
Indirizzi:
Cork Univ Hosp, Reg Adult Cyst Fibrosis Unit, Cork, Ireland Cork Univ Hosp Cork Ireland Reg Adult Cyst Fibrosis Unit, Cork, Ireland
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 11, volume: 94, anno: 2000,
pagine: 1092 - 1096
SICI:
0954-6111(200011)94:11<1092:FAIACF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; ANTIBODIES; DIAGNOSIS; FUMIGATUS; DISEASE;
Keywords:
cystic fibrosis; fungal atopy; allergic bronchopulmonary mycosis (ABPM); skin prick test (SPT); specific serum IgE (RAST);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Bredin, CP Cork Univ Hosp, Reg Adult Cyst Fibrosis Unit, Cork, Ireland Cork Univ Hosp Cork Ireland yst Fibrosis Unit, Cork, Ireland
Citazione:
M. Henry et al., "Fungal atopy in adult cystic fibrosis", RESP MED, 94(11), 2000, pp. 1092-1096

Abstract

This study set out to estimate the prevalence of atopy to a variety of common ubiquitous fungi, including A. fumigatus, in cystic fibrosis (CF), and to evaluate the investigations by which the diagnosis was made. Particular attention was paid to the usefulness of skin testing and immunoassays in detecting which patients had simple fungal atopy, and which patients were at high risk of developing allergic bronchopulmonary mycoses. This cross-sectional study included 21 adult CF patients and 20 matched controls. Serum samples were taken for the measurement of total serum IgE andspecific serum IgE to nine common fungi. Immediate hypersensitivity skin prick testing to each of the fungi was also performed. Simple fungal atopy was described in subjects fulfilling the following criteria: total serum IgE> 100 KU l(-1) with specific radioimmunoassay greater than or equal to grade 1 to at least one fungus and a positive skin prick test (SPT) greater than or equal to 3 mm to the same fungus. 'High risk' for developing allergicbronchopulmonary mycosis (ABPM) was described in subjects fulfilling the following criteria: total serum IgE > 200 KU l(-1) with specific radioimmunoassay greater than or equal to grade 2 to at least one fungus and a positive skin prick test (SPT) greater than or equal to 6 mm to the same fungus. The adult CF group had a significantly higher total SPT score (P = 0.005) and mean total serum IgE (P < 0.05) than controls. Forty-three percent of CF patients fulfilled the criteria for fungal atopy to at least a single fungus. Over half this group had an atopic tendency to more than one fungus. Nineteen percent of the CF group were at least 'high risk' of developing ABPM. Skin prick testing is a better marker of fungal atopy and a better predictor of those adult CF patients at higher risk of developing ABPM than specific radioimmunoassay serum testing. There is a high prevalence of fungal atopy in the adult CF population. Total serum IgE and skin prick testing are good predictors of fungal atopy andhelp predict those at risk of developing ABPM in CF.

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Documento generato il 21/01/21 alle ore 03:49:53