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Titolo:
Natural exposure to pollen reduces the threshold but does not change the pattern of response to the allergen in allergic subjects
Autore:
Dente, FL; Bacci, E; Di Franco, A; Giannini, D; Vagaggini, B; Paggiaro, PL;
Indirizzi:
Univ Pisa, Dept Cardiothorac, Resp Pathophysiol Unit, Pisa, Italy Univ Pisa Pisa Italy Cardiothorac, Resp Pathophysiol Unit, Pisa, Italy
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 11, volume: 94, anno: 2000,
pagine: 1073 - 1078
SICI:
0954-6111(200011)94:11<1073:NETPRT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE ASTHMATIC RESPONSES; BRONCHIAL RESPONSIVENESS; CHEMOTACTIC ACTIVITY; INHALED ALLERGEN; HYPERRESPONSIVENESS; EOSINOPHIL; INCREASE; HYPERREACTIVITY; BECLOMETHASONE; IMMUNOTHERAPY;
Keywords:
asthma; grass pollen allergy; bronchial challenge test; bronchial hyperresponsiveness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Dente, FL Osped Cisanello, Dipartimento Cardio Toracico, Sez Pneumol, Via Paradisa 2, I-56124 Pisa, Italy Osped Cisanello Via Paradisa 2 Pisa Italy I-56124 4 Pisa, Italy
Citazione:
F.L. Dente et al., "Natural exposure to pollen reduces the threshold but does not change the pattern of response to the allergen in allergic subjects", RESP MED, 94(11), 2000, pp. 1073-1078

Abstract

It is known that exposure to seasonal allergen in sensitized asthmatics increases non-specific bronchial responsiveness, but it is controversial if exposure to seasonal allergen influences the presence and the severity of the late asthmatic response (LAR) to allergen. Fifteen asthmatic subjects sensitized to grass pollen performed a specificbronchial provocative test (sBPT) with Phleum pratensis extract before andduring the pollen season. Changes of methacholine were also assessed. Allergen PD20FEV1 significantly decreased during the pollen season with respect to outside (allergen PD20FEV1, geometric mean: 0.10 vs. 0.23 biological units; P < 0.05), but the pattern of specific airway response did not change. Particularly, a consistent LAR was observed in three subjects outsidethe pollen season and in two subjects during the pollen season. Seven subjects with isolated early asthmatic response (EAR) outside the season did not show LAR after allergen inhalation during the pollen season. However, four of five subjects with slight LAR outside the pollen season (<Delta>FEV1% between 15 and 20%) lost LAR during season. Methacholine sensitivity increased slightly but significantly From outside to during the pollen season. This increase was greater in subjects with LAR outside the pollen season. The natural exposure to pollen induces an increase in bronchial sensitivity to allergen in sensitized subjects, but it does not induce LAR in subjects without LAR outside the pollen season.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 11:41:30